Molecular Formula | C16H13Cl2N5OS |
Molar Mass | 394.28 |
Density | 1.516±0.06 g/cm3(Predicted) |
Melting Point | 333-335°C |
Solubility | DMSO (Slightly) |
Appearance | Solid |
Color | Pale Yellow |
pKa | 10.92±0.70(Predicted) |
Storage Condition | Inert atmosphere,2-8°C |
Refractive Index | 1.716 |
Use | Dasatinib Intermediate |
Introduction | N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl) amino]-5-thiazolformamide is yellow or light yellow solid powder at room temperature and pressure. It is a multi-component heterocyclic compound and can be used as an intermediate in organic synthesis. |
Solubility | N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl) amino]-5-thiazolformamide has a certain solubility in dimethyl sulfoxide and methanol, and its solubility in water is very poor. |
Synthesis method | For the synthesis of N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl) amino]-5-thiazolformamide, according to the synthesis method reported in the literature, starting from its precursors 2-amino-N-(2-chloro-6-methylphenyl) thiazol-5-formamide and 4, 6-dichloro-2-methylpyrimidine, under alkaline conditions, the target product can be obtained through the aromatic nucleophilic substitution reaction of the amino group to the pyrimidine ring. |
Environmental hazard | N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl) amino]-5-thiazolformamide, as a nitrogen-containing polyheterocyclic organic compound, is more harmful to the water environment, do not allow undiluted or large quantities of products to come into contact with groundwater, waterways or sewage systems. |