2,2-difluoro-1-(pyridin-2-yl)ethan-1-one - Names and Identifiers
Name | 2,2-difluoro-1-(2-pyridyl)ethanone
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Synonyms | LogP 2-(Difluoroacetyl)pyridine 2,2-difluoro-1-(2-pyridyl)ethanone 2,2-Difluor-1-(pyridin-2-yl)ethanon 2,2-Dfluoro-1-(pyridin-2-yl)ethanone 2,2-Difluoro-1-(pyridin-2-yl)ethanone 2,2-Difluoro-1-(2-pyridinyl)-ethanone 2,2-difluoro-1-(pyridin-2-yl)ethanone ethanone, 2,2-difluoro-1-(2-pyridinyl)- Ethanone, 2,2-difluoro-1-(2-pyridinyl)- 2,2-difluoro-1-(pyridin-2-yl)ethan-1-one Ethanone, 2,2-difluoro-1-(2-pyridinyl)- (9CI)
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CAS | 80459-00-3
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InChI | InChI=1/C7H5F2NO/c8-7(9)6(11)5-3-1-2-4-10-5/h1-4,7H |
2,2-difluoro-1-(pyridin-2-yl)ethan-1-one - Physico-chemical Properties
Molecular Formula | C7 H5 F2 N O
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Molar Mass | 157.12 |
Density | 1.252±0.06 g/cm3(Predicted) |
Boling Point | 206.1±30.0 °C(Predicted) |
Flash Point | 78.4°C |
Vapor Presure | 0.242mmHg at 25°C |
pKa | 1.51±0.10(Predicted) |
Storage Condition | Inert atmosphere,Room Temperature |
Refractive Index | 1.464 |
2,2-difluoro-1-(pyridin-2-yl)ethan-1-one - Risk and Safety
Hazard Symbols | Xi - Irritant
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2,2-difluoro-1-(pyridin-2-yl)ethan-1-one - Introduction
2,2-difluoro-1-(2-pyridyl)ethanone is an organic compound with a chemical formula of C7H6F2NO and a molecular weight of 153.12. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: colorless liquid
-Melting point:-18 ℃
-Boiling point: 120-122 ℃
-Density: 1.245 g/mL
-Flammability: Flammable
-Solubility: Soluble in many organic solvents, such as ethanol, chloroform and dimethylformamide
Use:
- 2,2-difluoro-1-(2-pyridyl)ethanone is widely used as an important intermediate in organic synthesis. It can be used to synthesize other organic compounds, such as pharmaceuticals, pesticides, dyes and coordination compounds.
-It can also be used as a marker substance in archaeological research to help determine the age of ancient objects.
Preparation Method:
-2,2-difluororo-1-(2-pyridyl)ethanone can be obtained by reacting 2-pyridine ethanol with difluoromethanesulfonyl fluoride. The specific preparation method is as follows:
1. 2-Pyridine ethanol was added to the reactor.
2. Thionyl chloride was added to the reactor.
3. At low temperature, add difluoromethanesulfonyl fluoride.
4. After completion of the reaction, the product was obtained by cooling and filtration.
Safety Information:
- 2,2-difluoro-1-(2-pyridyl)ethanone is irritating and corrosive, and contact with skin and eyes may cause irritation or injury.
-Wear protective gloves, goggles and protective clothing when using.
-Avoid inhaling its vapor and ensure that it is operated in a well-ventilated place.
-storage should be sealed in a cool, dry place, away from fire and oxidant.
Please note: For the use of this compound, please follow the correct use and handling of chemicals, and comply with local safety regulations.
Last Update:2024-04-09 15:18:00