ChemBK
  • Home
  • Product Category

1-alpha-Narcotine

(S,R)-noscapine

CAS: 128-62-1

Molecular Formula: C22H23NO7

  1. Home
  2. Product Category
  3. other
  4. other
  5. 1-alpha-Narcotine

1-alpha-Narcotine - Names and Identifiers

Name (S,R)-noscapine
Synonyms nsc5366
narcotine
(S,R)-noscapine
1-alpha-Narcotine
,2,3,4-tetrahydroisoquinaline
5-g)isoquinolin-5-yl)-,(s-(r*,s*))-3-dioxolo(4
5-g]isoquinolin-5-yl)-,[s-(theta,s)]-3-dioxolo[4
6,7-dimethoxy-3-(4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-2-benzofuran-1(3H)-one
6,7-Dimethoxy-3-(4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-2-benzofuran-1(3H)-one
6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3H-isobenzofuran-1-one
(3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one
(3R)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one
[S-(R*,S*)]-6,7-Dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-1(3H)-Isobenzofuranone
1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-, [S-(R*,S*)]-
(3R)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one hydrochloride
CAS 128-62-1
EINECS 204-899-2
InChI InChI=1/C22H23NO7.ClH/c1-23-8-7-11-9-14-20(29-10-28-14)21(27-4)15(11)17(23)18-12-5-6-13(25-2)19(26-3)16(12)22(24)30-18;/h5-6,9,17-18H,7-8,10H2,1-4H3;1H/t17-,18-;/m1./s1

1-alpha-Narcotine - Physico-chemical Properties

Molecular FormulaC22H23NO7
Molar Mass413.42
Density1.395
Melting Point174-176°C(lit.)
Boling Point532.6°C (rough estimate)
Specific Rotation(α)-200 º (c=1 in chloroform)
Flash Point308.5°C
Water Solubility302.9mg/L(25 ºC)
Solubility Practically insoluble in water, soluble in acetone, slightly soluble in ethanol (96 per cent). It dissolves in strong acids; on dilution of the solution with water, the base may be precipitated.
Vapor Presure4.83E-14mmHg at 25°C
AppearanceCrystalline solid
ColorOrthorhombic prisms or stout needles from alc
Merck13,6752
pKa7.8(at 25℃)
Storage Condition-20°C Freezer, Under Inert Atmosphere
Refractive Index1.5614 (estimate)
Physical and Chemical PropertiesColorless crystalline powder or glossy prismatic or flaky crystals; Odorless and tasteless. Almost insoluble in water, slightly soluble in ethanol and ether, soluble in chloroform.

1-alpha-Narcotine - Risk and Safety

Hazard SymbolsXn - Harmful
Harmful
Risk Codes22 - Harmful if swallowed
Safety Description24/25 - Avoid contact with skin and eyes.
UN IDs1544
WGK Germany3
RTECSRD2625000
HS Code29329990
Hazard Class6.1(b)
Packing GroupIII
Toxicitycyt-ham:lng 100 mg/L ATSUDG (4),41,80

1-alpha-Narcotine - Standard

Authoritative Data Verified Data

This product is (S-R 'S')]-6, 7-dimethoxy-3-(5,6, 7, 8-tetrahydro-6-methyl-4-methoxy-1, 3-dioxolene [4,5-g]-5-isoquinolyl)-1(3H)-isobenzofuranone. Calculated as dried product, the content of C22H23N07 shall not be less than 99.0%.

Last Update：2024-01-02 23:10:35

1-alpha-Narcotine - Trait

Authoritative Data Verified Data
  • This product is white crystalline powder or glossy prismatic crystal; Odorless.
  • This product is soluble in chloroform, slightly soluble in ethanol or ether, and almost insoluble in water.

melting point

The melting point of this product (General 0612) is 174~177°C.

specific rotation

take this product, precision weighing, plus O. 1 mol/L hydrochloric acid solution was dissolved and quantitatively diluted to give a solution containing about 20mg per 1 ml, which was measured according to law (General 0621). The specific rotation was 42 ° to 48 °.

Last Update：2022-01-01 11:54:19

1-alpha-Narcotine - Differential diagnosis

Authoritative Data Verified Data
  1. take about 1 mg of this product, add 1 drop of sulfuric acid to dissolve, into a yellow-green solution, warm red, and finally turned purple.
  2. take about 1 mg of this product, add 1 drop of molybdenum sulfuric acid test solution, show dark green, gradually change to purple after warming.
  3. The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 609).
Last Update：2022-01-01 11:54:20

1-alpha-Narcotine - Exam

Authoritative Data Verified Data

clarity and color of acetone solution

take 0.2g of this product, add acetone 10ml to dissolve, the solution should be clear and colorless; If the color is colored, compared with the yellow No. 2 Standard Colorimetric liquid (General rule 0901 first method), not deeper.

Related substances

take this product, add the mobile phase to dissolve and dilute to make a solution containing lmg per lml as a test solution; Take lml for precision measurement and put it in a 100ml measuring flask, dilute to the scale with the mobile phase, shake, and serve as a control solution. According to the high performance liquid chromatography (General 0512) test, using eighteen alkyl silane bonded silica gel as filler; Methanol -0.lmol /L sodium dihydrogen phosphate solution (85:15) as mobile phase; The detection wavelength was 290nm. The number of the theoretical plates shall not be less than 2000 based on the calculation of the Ding peak. 20 u1 of test solution and 20 u1 of control solution were respectively injected into human liquid chromatograph, and the chromatogram was recorded to 2.5 times of the retention time of principal component peak. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%).

loss on drying

take this product, dry to constant weight at 105°C, weight loss shall not exceed 1.0% (General rule 0831).

ignition residue

not more than 0.1% (General rule 0841).

Last Update：2022-01-01 11:54:21

1-alpha-Narcotine - Content determination

Authoritative Data Verified Data

take about 0.3g of this product, precision weighing, add glacial acetic acid 10ml dissolved, add crystal violet indicator solution 1 drop, with perchloric acid titration solution (0.1 mol/L) titration to a clear blue color of the solution, and the results of the titration were corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 41.34mg of C22H23NO7.

Last Update：2022-01-01 11:54:21

1-alpha-Narcotine - Category

Authoritative Data Verified Data

antitussive drugs.

Last Update：2022-01-01 11:54:21

1-alpha-Narcotine - Storage

Authoritative Data Verified Data

light shielding, sealed storage.

Last Update：2022-01-01 11:54:21

1-alpha-Narcotine - Natcodine tablets

Authoritative Data Verified Data

This product contains 93.0% ~ 107.0% of the label amount of nacrine (C22H23N07).

trait

This product is sugar-coated tablets, White after removing the coating.

identification

take an appropriate amount of fine powder of this product (about 20mg equivalent to that of nacrodine), add 10ml of chloroform, stir to dissolve nacrosine, filter, and evaporate the filtrate on a water bath, the residue showed the same reaction according to the test of identification (1) and (2) under the nacrine.

examination

  • Content uniformity: Take 1 tablet of this product, grind it finely, add an appropriate amount of ethanol, grind it and transfer it to a 50ml measuring flask, fully shake it to dissolve the nacrine, then dilute it to the scale with ethanol, shake well, filter, Take 5ml of the filtrate accurately, put it in a 25ml measuring flask, dilute it with ethanol to the scale, shake well, and use it as a test solution, precision weighing, dissolved in ethanol and quantitatively diluted to make a solution containing 40ug per 1 ml, as a reference solution. According to UV-visible spectrophotometry (General rule 0401), measure the absorbance at the wavelength of 310mn respectively, calculate the content, should comply with the regulations (General rule 0941).
  • others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).

Content determination

Take 30 tablets of this product, remove the coating, precision weighing, fine, precision weighing an appropriate amount (about equivalent to 0.lg), add chloroform 20ml, shake, dissolve nacropin, filter, wash the container and filter with chloroform for 8 times, 5ml each time, combine the wash solution and filtrate, add glacial acetic acid 10ml, crystal violet indicator solution 1 drop, titrated with perchloric acid titration solution (0.05mol/L) to a clear blue solution, and the titration results were corrected with a blank test. Per 1 ml of perchloric acid titration solution (0.05mol/L) corresponds to 20.67mg of C22H23N07.

category storage

same as that of Codin.

specification

lOmg

Last Update：2022-01-01 11:54:22
1-alpha-Narcotine
Supplier List
Shanghai Macklin Biochemical Co., Ltd
Featured ProductsSpot supply
Product Name: Narcotine Visit Supplier Webpage Request for quotation
CAS: 128-62-1
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328 Click to send a QQ message
WhatsApp: +86-18821248368
MedChemExpress (MCE)
Multiple SpecificationsSpot supply
Product Name: Noscapine Visit Supplier Webpage Request for quotation
CAS: 128-62-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
　　　　 tech@medchemexpress.com
Mobile: 609-228-6898
SKYRUN INDUSTRIAL CO.,LTD
Spot supply
Product Name: noscapin Visit Supplier Webpage Request for quotation
CAS: 128-62-1
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185 Click to send a QQ messageSend QQ message
Wechat: chinaskyrun
SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
Spot supply
Product Name: Noscapine Visit Supplier Webpage Request for quotation
CAS: 128-62-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922 Click to send a QQ message
Wechat: 18621343501
WhatsApp: +86-18621343501
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: (S,R)-noscapine Request for quotation
CAS: 128-62-1
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple Specifications
Product Name: Noscapine Visit Supplier Webpage Request for quotation
CAS: 128-62-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Shanghai Macklin Biochemical Co., Ltd
Featured ProductsSpot supply
Product Name: Narcotine Visit Supplier Webpage Request for quotation
CAS: 128-62-1
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328 Click to send a QQ message
WhatsApp: +86-18821248368
MedChemExpress (MCE)
Multiple SpecificationsSpot supply
Product Name: Noscapine Visit Supplier Webpage Request for quotation
CAS: 128-62-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
　　　　 tech@medchemexpress.com
Mobile: 609-228-6898
SKYRUN INDUSTRIAL CO.,LTD
Spot supply
Product Name: noscapin Visit Supplier Webpage Request for quotation
CAS: 128-62-1
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185 Click to send a QQ messageSend QQ message
Wechat: chinaskyrun
SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
Spot supply
Product Name: Noscapine Visit Supplier Webpage Request for quotation
CAS: 128-62-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922 Click to send a QQ message
Wechat: 18621343501
WhatsApp: +86-18621343501
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: (S,R)-noscapine Request for quotation
CAS: 128-62-1
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple Specifications
Product Name: Noscapine Visit Supplier Webpage Request for quotation
CAS: 128-62-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
View History
1-alpha-Narcotine
1-十四碳烯,正十四烯
2-溴-3-氯异烟酸甲酯
Disodium (1-((5-chloro-2-hydroxy-4-nitrophenyl)azo)-2-naphtholato(2-))(3-hydroxy-4-((2-hydroxy-1-naphthyl)azo)naphthalene-1-sulphonato(3-))chromate(2-)
4-isothiocyanato-N-(3-methoxy-2-pyrazinyl)benzenesulfonamide
地奥司明EP杂质C(异柠檬醛)
N-{[5-(2-氯丙酰基)噻吩-2-基]甲基}乙酰胺
  • Home
  • Product Category

© 2015, 2023 ChemBK.com All Rights Reserved | Build: 20230617001