中文名 | 雷公藤内酯甲 |
英文名 | (3beta,22alpha)-3-hydroxy-22,29-epoxyolean-12-en-29-one |
别名 | 雷公藤内酯A 雷公藤内酯甲 雷公藤内酯甲(标准品) 雷公藤酯甲(雷公藤内酯甲) WILFORLIDE A 雷公藤内酯甲 |
英文别名 | Regelide Wilforlide WOLFORLIDE A Wilforlide A WILFORLIDE A Wilforlide A (Regelide Wilforlide A 84104-71-2 4,2-(Epoxymethano)picene, olean-12-en-29-oicacid deriv (3beta,22alpha)-3-Hydroxy-22,29-epoxyolean-12-en-29-one (3beta,22alpha)-3-hydroxy-22,29-epoxyolean-12-en-29-one olean-12-en-29-one, 22,29-epoxy-3-hydroxy-, (3beta,22alpha)- Olean-12-en-29-oicacid, 3,22-dihydroxy-, γ-lactone, (3β,20α,22α)- |
CAS | 84104-71-2 |
化学式 | C30H46O3 |
分子量 | 454.68 |
InChI | InChI=1/C30H46O3/c1-25(2)20-10-13-30(7)21(28(20,5)12-11-22(25)31)9-8-18-19-16-26(3)17-23(33-24(26)32)27(19,4)14-15-29(18,30)6/h8,19-23,31H,9-17H2,1-7H3/t19-,20-,21+,22-,23-,26-,27+,28-,29+,30+/m0/s1 |
密度 | 1.12±0.1 g/cm3(Predicted) |
熔点 | 318-320 °C |
沸点 | 555.0±50.0 °C(Predicted) |
比旋光度 | (c, 1 in CHCl3)-34.2 |
闪点 | 208.6°C |
蒸汽压 | 1.24E-14mmHg at 25°C |
溶解度 | 难溶于水,易溶于氯仿、乙酸乙酯。 |
折射率 | 1.563 |
酸度系数 | 15.17±0.70(Predicted) |
存储条件 | 2-8℃ |
外观 | 粉末或结晶 |
颜色 | White to Light yellow |
物化性质 | 白色粉末,可溶于甲醇、乙醇、DMSO等有机溶剂,来源于雷公藤。 |
MDL号 | MFCD00272168 |
体内研究 | Wilforlide A (60-300 μg/kg) markedly inhibits mice auricular swelling induced by dimethylbenzene in ICR mice. Wilforlide A exhibits inhibition rates with 50.9% and 12.29% for high dose and low dose Wilforlide A, resepectively. Wilforlide A (30-150 μg/kg) markedly inhibits rat granulation induced by tampon. |
参考资料 展开查看 | 1. [IF=3.337] Yunxiang Cao et al.Wilforlide A ameliorates the progression of rheumatoid arthritis by inhibiting M1 macrophage polarization.J Pharmacol Sci. 2021 Nov;: |
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