Name | (3beta,22alpha)-3-hydroxy-22,29-epoxyolean-12-en-29-one |
Synonyms | Regelide Wilforlide WOLFORLIDE A Wilforlide A WILFORLIDE A Wilforlide A (Regelide Wilforlide A 84104-71-2 4,2-(Epoxymethano)picene, olean-12-en-29-oicacid deriv (3beta,22alpha)-3-Hydroxy-22,29-epoxyolean-12-en-29-one (3beta,22alpha)-3-hydroxy-22,29-epoxyolean-12-en-29-one olean-12-en-29-one, 22,29-epoxy-3-hydroxy-, (3beta,22alpha)- Olean-12-en-29-oicacid, 3,22-dihydroxy-, γ-lactone, (3β,20α,22α)- |
CAS | 84104-71-2 |
InChI | InChI=1/C30H46O3/c1-25(2)20-10-13-30(7)21(28(20,5)12-11-22(25)31)9-8-18-19-16-26(3)17-23(33-24(26)32)27(19,4)14-15-29(18,30)6/h8,19-23,31H,9-17H2,1-7H3/t19-,20-,21+,22-,23-,26-,27+,28-,29+,30+/m0/s1 |
Molecular Formula | C30H46O3 |
Molar Mass | 454.68 |
Density | 1.12±0.1 g/cm3(Predicted) |
Melting Point | 318-320 °C |
Boling Point | 555.0±50.0 °C(Predicted) |
Specific Rotation(α) | (c, 1 in CHCl3)-34.2 |
Flash Point | 208.6°C |
Solubility | Insoluble in water, easily soluble in chloroform and ethyl acetate. |
Vapor Presure | 1.24E-14mmHg at 25°C |
Appearance | Colorless needle crystal |
Color | White to Light yellow |
pKa | 15.17±0.70(Predicted) |
Storage Condition | 2-8℃ |
Refractive Index | 1.563 |
MDL | MFCD00272168 |
Physical and Chemical Properties | White powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Tripterygium wilfordii. |
In vivo study | Wilforlide A (60-300 μg/kg) markedly inhibits mice auricular swelling induced by dimethylbenzene in ICR mice. Wilforlide A exhibits inhibition rates with 50.9% and 12.29% for high dose and low dose Wilforlide A, resepectively. Wilforlide A (30-150 μg/kg) markedly inhibits rat granulation induced by tampon. |
Reference Show more | 1. [IF=3.337] Yunxiang Cao et al.Wilforlide A ameliorates the progression of rheumatoid arthritis by inhibiting M1 macrophage polarization.J Pharmacol Sci. 2021 Nov;: |
biological activity | Wilforlide A is an active compound in Tripterygium glycosides, A traditional Chinese medicine used in the treatment of autoimmune diseases. |
Use | Anti-tumor and immunosuppressive effects, can be used for the treatment of rheumatoid arthritis. for content determination/identification/pharmacological experiments. Pharmacological Efficacy: is the traditional treatment of rheumatoid arthritis, triptolide is one of its effective ingredients, has a strong anti-tumor and immunosuppressive effect. There is a greater toxicity. |