中文名 | 泰地罗新 |
英文名 | Tildipirosin |
别名 | 泰地罗新 替地匹罗星 化合物CX5461 泰地罗新溶液,100PPM TILDIPIROSIN泰地罗新 |
英文别名 | TIP Zuprevo. ZUPREVO. Tildipirosin tildipirosin TILDIPIROSIN Tildipirosin Solution, 100ppm 20-Deoxo-23-deoxy-5-O-[3,6-dideoxy-3-(dimethylamino)-beta-D-glucopyranosyl]-20,23-di-1-piperidinylty 20-Deoxo-23-deoxy-5-O-[3,6-dideoxy-3-(dimethylamino)-beta-D-glucopyranosyl]-20,23-di-1-piperidinyltylonolide Tylonolide, 20-deoxo-23-deoxy-5-O-[3,6-dideoxy-3-(dimethylamino)-β-D-glucopyranosyl]-20,23-di-1-piperidinyl- |
CAS | 328898-40-4 |
化学式 | C41H71N3O8 |
分子量 | 734.02 |
密度 | 1.15 |
熔点 | >110°C (dec.) |
沸点 | 846.8±65.0 °C(Predicted) |
溶解度 | 氯仿 (微溶),DMSO (微溶),甲醇 (微溶) |
酸度系数 | 13.18±0.70(Predicted) |
存储条件 | 2-8°C |
外观 | 固体 |
颜色 | Off-White to Pale Beige |
物化性质 | 泰地罗新是最新动物专用的大环内酯类半合成抗生素,为泰乐菌素的衍生物。分子式为C41H71N3O8,分子量为734.02,白色至淡黄色粉末,泰地罗新以多晶型物存在,微溶于水,可溶于极性有机溶剂(如甲醇、丙酮等)。 |
体外研究 | Tildipirosin exhibits the inhibitory effect on C. coli species, and 23 of 31 (74%) isolates have MICs of 8 or 16 μg/mL while 8 of 31 (26%) have MIC >256 μg/mL. MICs against C. jejuni are 8-64 μg/mL. Tildipirosin against S. enterica and E. coli are 2-8 μg/mL. Tildipirosin inhibits the treponeme isolates form from CODD lesions from 19 sheep, with MIC90 of 0.0469 mg/L. The P. multocida B130 clones show the MIC of 0.25 mg/L for tildipirosin. The 10 P. multocida isolates that carry only erm(42) exhibit MIC of 16-32 mg/L for tildipirosin. The single M. haemolytica that harbours only erm(42) shows MIC of 32 mg/L for tildipirosin. |
体内研究 | The mean percentage of lung consolidation for tildipirosin (4 mg/kg, s.c.)-treated calves is significantly lower than those for tulathromycin-treated and control calves. Metaphylactic administration of tildipirosin to calves 5 days prior to H somni challenge prevents subsequent culture of the pathogen from bronchial secretions and is more effective in minimizing clinical disease and lung lesions than is metaphylactic administration of tulathromycin. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 1.362 ml | 6.812 ml | 13.624 ml |
5 mM | 0.272 ml | 1.362 ml | 2.725 ml |
10 mM | 0.136 ml | 0.681 ml | 1.362 ml |
5 mM | 0.027 ml | 0.136 ml | 0.272 ml |
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