Molecular Formula | C41H71N3O8 |
Molar Mass | 734.02 |
Density | 1.15 |
Melting Point | >110°C (dec.) |
Boling Point | 846.8±65.0 °C(Predicted) |
Solubility | Chloroform (Sparingly), DMSO (Slightly), Methanol (Slightly) |
Appearance | Solid |
Color | Off-White to Pale Beige |
pKa | 13.18±0.70(Predicted) |
Storage Condition | 2-8°C |
Physical and Chemical Properties | Tiallox is the latest animal-specific macrolide Semisynthetic Antibiotic, a derivative of Tylosin. The molecular formula is C41H71N3O8, molecular weight is 734.02, white to light yellow powder, with polymorph existing, slightly soluble in water, soluble in polar organic solvents (such as methanol, acetone, etc.). |
In vitro study | Tildipirosin exhibits the inhibitory effect on C. coli species, and 23 of 31 (74%) isolates have MICs of 8 or 16 μg/mL while 8 of 31 (26%) have MIC >256 μg/mL. MICs against C. jejuni are 8-64 μg/mL. Tildipirosin against S. enterica and E. coli are 2-8 μg/mL. Tildipirosin inhibits the treponeme isolates form from CODD lesions from 19 sheep, with MIC90 of 0.0469 mg/L. The P. multocida B130 clones show the MIC of 0.25 mg/L for tildipirosin. The 10 P. multocida isolates that carry only erm(42) exhibit MIC of 16-32 mg/L for tildipirosin. The single M. haemolytica that harbours only erm(42) shows MIC of 32 mg/L for tildipirosin. |
In vivo study | The mean percentage of lung consolidation for tildipirosin (4 mg/kg, s.c.)-treated calves is significantly lower than those for tulathromycin-treated and control calves. Metaphylactic administration of tildipirosin to calves 5 days prior to H somni challenge prevents subsequent culture of the pathogen from bronchial secretions and is more effective in minimizing clinical disease and lung lesions than is metaphylactic administration of tulathromycin. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 1.362 ml | 6.812 ml | 13.624 ml |
5 mM | 0.272 ml | 1.362 ml | 2.725 ml |
10 mM | 0.136 ml | 0.681 ml | 1.362 ml |
5 mM | 0.027 ml | 0.136 ml | 0.272 ml |