中文名 | 斯利潘托 |
英文名 | Stiripentol |
别名 | 斯利潘托 司替戊醇 木犀草醇 1-(苯并[D][1,3]二氧杂环戊烯-5-基-4,4-二甲基戊-1-烯-3-醇 |
英文别名 | bcx2600 Diacomit 256-480-9 Stiripentol STIRIPENTOL 1-(1,3-BENZODIOXOL-5YL)-4,4-DIMETHYL-1-PENTEN-3-OL 1-(1,3-benzodioxol-5-yl)-4,4-dimethyl-1-penten-3-o 1-(1,3-benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-ol 4,4-dimethyl-1-(3,4-methylenedioxyphenyl)-1-penten-3-o 4,4-dimethyl-1-(3,4-methylenedioxyphenyl)-1-penten-3-ol (1E)-1-(1,3-benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-ol (RS)-(E)-4,4-dimethyl-1-[3,4(methylenedioxy)-phenyl]-1-penten-3-ol |
CAS | 49763-96-4 |
EINECS | 256-480-9 |
化学式 | C14H18O3 |
分子量 | 234.29 |
InChI | InChI=1/C14H18O3/c1-14(2,3)13(15)7-5-10-4-6-11-12(8-10)17-9-16-11/h4-8,13,15H,9H2,1-3H3/b7-5+ |
InChIKey | IBLNKMRFIPWSOY-FNORWQNLSA-N |
密度 | 1.139±0.06 g/cm3(Predicted) |
熔点 | 73-74°C |
沸点 | 365.4±11.0 °C(Predicted) |
闪点 | 174.8°C |
蒸汽压 | 5.54E-06mmHg at 25°C |
溶解度 | DMSO: ≥ 20 mg/mL |
折射率 | 1.578 |
酸度系数 | 14.45±0.20(Predicted) |
存储条件 | -20°C |
外观 | 粉末 |
颜色 | white to beige |
体外研究 | Stiripentol (STP) is an anticonvulsant agent, which can inhibit N-demethylation of CLB to N-desmethylclobazam (NCLB) mediated by CYP3A4 (noncompetitively) and CYP2C19 (competitively). The inhibition of CLB demethylation by Stiripentol (STP) is best described by a noncompetitive inhibition model with apparent K i =1.6 μM for the cDNA-expressing CYP3A4 and by a competitive inhibition model with K i =0.52 μM for the cDNA-expressing CYP2C19. Formation of OH-NCLB from NCLB by cDNA-expressing CYP2C19 is competitively inhibited by Stiripentol (STP) with a K i =0.14 μM. |
体内研究 | In mice treating with Stiripentol (STP) monotherapy, the difference between BT 1 (39.67±1.09°C) and BT 2 (41.32±1.05°C) reaches statistical significance (t=3.097, p<0.05). The difference in BT 2 between Stiripentol (STP) monotherapy and CLB monotherapy is statistically significant (t=2.615, p<0.05). In mice treating with Stiripentol (STP)+CLB combination therapy, the difference between BT 1 (40.18±0.58°C) and BT 2 (43.03±0.49°C) reaches statistical significance (t=10.44, p<0.01). |
危险品标志 | Xn - 有害物品 |
风险术语 | 22 - 吞食有害。 |
WGK Germany | 3 |
RTECS | SB3393000 |
下游产品 | 1-(3,4-METHYLENEDIOXY-PHENYL)-4,4-DIMETHYL-PENT-1-EN-3-ONE |