临床上试用于防治化疗和放疗引起的白细胞减少症。
中文名 | 千金藤碱 |
英文名 | cepharanthine |
别名 | 千金藤素 千金藤碱 千金藤啶碱 头花千金藤碱 千金藤素(千金藤碱) 千金藤素(千金藤提取物) |
英文别名 | Stephanotis cepharanthine 22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.2~16,19~.1~3,10~.1~21,25~.0~4,8~.0~14,39~.0~31,35~]nonatriaconta-1(33),3,8,10(39),16,18,21(36),22,24,31,34,37-dodecaene (non-preferred name) (14S,27R)-22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.2~16,19~.1~3,10~.1~21,25~.0~4,8~.0~14,39~.0~31,35~]nonatriaconta-1(33),3,8,10(39),16,18,21(36),22,24,31,34,37-dodecaene (non-preferred name) |
CAS | 481-49-2 |
化学式 | C37H38N2O6 |
分子量 | 606.72 |
InChI | InChI=1/C37H38N2O6/c1-38-13-11-24-18-31(41-4)33-20-27(24)28(38)16-23-7-10-30(40-3)32(17-23)44-26-8-5-22(6-9-26)15-29-35-25(12-14-39(29)2)19-34-36(37(35)45-33)43-21-42-34/h5-10,17-20,28-29H,11-16,21H2,1-4H3 |
密度 | 1.227g/cm3 |
熔点 | 145-155° |
沸点 | 654.03°C (rough estimate) |
比旋光度 | D20 +277° (c = 2 in chloroform) |
溶解度 | DMSO: 125毫克/毫升 (206.03毫米; 需要超声波) |
折射率 | 1.608 |
酸度系数 | 7.61±0.20(Predicted) |
存储条件 | under inert gas (nitrogen or Argon) at 2-8°C |
外观 | 白色晶体 |
MDL号 | MFCD00210482 |
参考资料 展开查看 | 1. 尹杨峰 蒋磊.千金藤素通过MAT2B调节MAPK信号通路对宫颈癌细胞增殖和凋亡的影响[J].中国医药生物技术 2020 15(02):183-189. 2. [IF=5.64] Wu Dousheng et al."Oleanolic Acid Induces the Type III Secretion System of Ralstonia solanacearum."Front Microbiol. 2015 Dec;0:1466 3. [IF=4.739] Xuan Zhang et al."Cepharanthine, a novel selective ANO1 inhibitor with potential for lung adenocarcinoma therapy."Bba-Mol Cell Res. 2021 Nov;1868:119132 4. [IF=3.575] Xiang-Yan Wei et al."Antinociceptive activities and mechanism of action of Cepharanthine."BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2022 May;: |
临床上试用于防治化疗和放疗引起的白细胞减少症。
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