Name | cepharanthine |
Synonyms | Stephanotis cepharanthine 22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.2~16,19~.1~3,10~.1~21,25~.0~4,8~.0~14,39~.0~31,35~]nonatriaconta-1(33),3,8,10(39),16,18,21(36),22,24,31,34,37-dodecaene (non-preferred name) (14S,27R)-22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.2~16,19~.1~3,10~.1~21,25~.0~4,8~.0~14,39~.0~31,35~]nonatriaconta-1(33),3,8,10(39),16,18,21(36),22,24,31,34,37-dodecaene (non-preferred name) |
CAS | 481-49-2 |
InChI | InChI=1/C37H38N2O6/c1-38-13-11-24-18-31(41-4)33-20-27(24)28(38)16-23-7-10-30(40-3)32(17-23)44-26-8-5-22(6-9-26)15-29-35-25(12-14-39(29)2)19-34-36(37(35)45-33)43-21-42-34/h5-10,17-20,28-29H,11-16,21H2,1-4H3 |
Molecular Formula | C37H38N2O6 |
Molar Mass | 606.72 |
Density | 1.227g/cm3 |
Melting Point | 145-155° |
Boling Point | 654.03°C (rough estimate) |
Specific Rotation(α) | D20 +277° (c = 2 in chloroform) |
Solubility | DMSO : 125 mg/mL (206.03 mM; Need ultrasonic) |
Appearance | White crystal |
pKa | 7.61±0.20(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Refractive Index | 1.608 |
MDL | MFCD00210482 |
Use | Used as an analgesic, can be used to promote the proliferation of white blood cells. |
Toxicity | Toxic |
Reference Show more | 1. Yin, yang, Feng, Lei Jiang. Effect of makinin on proliferation and apoptosis of cervical cancer cells by regulating MAPK signaling pathway through MAT2B [J]. China Medical Biotechnology 2020 15(02):183-189. 2. [IF = 5.64] Wu Dousheng et al."Oleanolic acids the Type III secret System of Ralstonia solanacearum." Front Microbiol. 2015 Dec;0:1466 3. [IF = 4.739] Xu Zhang et al."Cepharanthine, a novel selective ANO1 inhibitor with potential for lung adenocarcinoma therapy." Bba-Mol Cell Res. 2021 Nov;1868:119132 4. [IF = 3.575] Xiang-Yan Wei et al."Antinociceptive activities and mechanism of action of Cepharanthine."BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2022 May ;: |
clinical trial in the prevention and treatment of chemotherapy and radiotherapy induced leukopenia.