中文名 | O-去甲荷叶碱 |
英文名 | ORTHO-NORNUCIFERINE |
别名 | N-甲基巴婆碱 O-去甲荷叶碱 O-去甲基荷叶碱 O-去甲荷叶碱(N-甲基巴婆碱) |
英文别名 | floribundine ORTHO-NORNUCIFERINE O-demethyl nuciferine (6aR)-5,6,6a,7-Tetrahydro-1-methoxy-6-methyl-4H-dibenzo[de,g]quinolin-2-ol 4H-Dibenzo[de,g]quinolin-2-ol, 5,6,6a,7-tetrahydro-1-methoxy-6-methyl-, (6aR)- |
CAS | 3153-55-7 |
化学式 | C18H19NO2 |
分子量 | 281.35 |
密度 | 1.216±0.06 g/cm3(Predicted) |
熔点 | 195-197℃ (ethyl acetate ) |
沸点 | 451.4±45.0 °C(Predicted) |
酸度系数 | 10.12±0.20(Predicted) |
存储条件 | 2-8℃ |
体外研究 | O-Nornuciferine has an IC 50 of 7.91 μM in vitro hERG blockages measured in HEK293 cells. O-Nornuciferine (100 μM) has 47% hERG channel inhibition in Xenopus oocytes by lotus alkaloids. |
参考资料 展开查看 | 1. [IF=5.279] Xianbao Deng et al."Analysis of Isoquinoline Alkaloid Composition and Wound-Induced Variation in Nelumbo Using HPLC-MS/MS."J Agr Food Chem. 2016;64(5):1130–1136 2. [IF=4.032] Qiu-yue Xiao et al."A network pharmacology-based study on key pharmacological pathways and targets of Qi Fu Yin acting on Alzheimer's disease."Exp Gerontol. 2021 Jul;149:111336 3. [IF=1.902] Yongjing Liu et al."Evaluation of Green and Efficient deep eutectic solvents as media for extracting Alkaloids from Lotus Leaf."Biomedical Chromatography. 2021 Dec 06 |
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