Molecular Formula | C18H19NO2 |
Molar Mass | 281.35 |
Density | 1.216±0.06 g/cm3(Predicted) |
Melting Point | 195-197℃ (ethyl acetate ) |
Boling Point | 451.4±45.0 °C(Predicted) |
pKa | 10.12±0.20(Predicted) |
Storage Condition | 2-8℃ |
In vitro study | O-Nornuciferine has an IC 50 of 7.91 μM in vitro hERG blockages measured in HEK293 cells. O-Nornuciferine (100 μM) has 47% hERG channel inhibition in Xenopus oocytes by lotus alkaloids. |
Reference Show more | 1. [IF=5.279] Xianbao Deng et al."Analysis of Isoquinoline Alkaloid Composition and Wound-Induced Variation in Nelumbo Using HPLC-MS/MS."J Agr Food Chem. 2016;64(5):1130–1136 2. [IF=4.032] Qiu-yue Xiao et al."A network pharmacology-based study on key pharmacological pathways and targets of Qi Fu Yin acting on Alzheimer's disease."Exp Gerontol. 2021 Jul;149:111336 3. [IF=1.902] Yongjing Liu et al."Evaluation of Green and Efficient deep eutectic solvents as media for extracting Alkaloids from Lotus Leaf."Biomedical Chromatography. 2021 Dec 06 |
biological activity | O-Noruciferine is a porphyrin alkaloid of lotus leaf, which is a potent hERG channel inhibitor. |