中文名 | 买麻藤醇 |
英文名 | Gnetol |
别名 | 买麻藤醇 2,6,3',5'-四羟基二苯乙烯 |
英文别名 | Gnetol -2-(3,5-Dihydroxystyryl) 2,3',5',6-Tetrahydroxy-trans-stilbene (E)-2-(3,5-Dihydroxystyryl)benzene-1,3-diol 2-[2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol 2-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,3-benzenediol 1,3-Benzenediol, 2-[(1E)-2-(3,5-dihydroxyphenyl)ethenyl]- |
CAS | 86361-55-9 |
EINECS | 617-839-9 |
化学式 | C14H12O4 |
分子量 | 244.24 |
密度 | 1.468±0.06 g/cm3(Predicted) |
熔点 | 271°C(lit.) |
沸点 | 540.8±30.0 °C(Predicted) |
溶解度 | 氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。 |
酸度系数 | 9.06±0.40(Predicted) |
存储条件 | under inert gas (nitrogen or Argon) at 2-8°C |
外观 | 粉末或结晶 |
颜色 | White to Light yellow to Light orange |
最大波长(λmax) | ['337nm(EtOH)(lit.)'] |
MDL号 | MFCD12405548 |
体外研究 | The antiproliferative activities of Gnetol are tested in HCT-116, Hep-G2, MDA-MB-231, and PC-3 cell lines by measuring cell viability after treatment with 4.1 μM, 40.9 μM, 204.7 μM, 409.4 μM, and 1023.6 μM. Gnetol shows concentration-dependent reductions in cell viability in cancer cell lines with greatest activity in colorectal cancer. Gnetol at 200 µg/mL significantly offers the highest protection of 54.3% against the toxicant. A lower dose of Gnetol (50 µg/mL) also shields the cell line from the toxic effects of CCl4. The ligand molecule TGF-β and PPARα protein show that Gnetol has the binding affinity of 7.0 and 8.4, respectively. |
体内研究 | Male Sprague-Dawley rats were cannulated and dosed either intravenously with Gnetol (10 μg/kg) or orally (100 mg/kg). After oral and intravenous administration, Gnetol is detected in both serum and urine as the parent compound and as a glucuronidated metabolite. The bioavailability of Gnetol is determined to be 6%. Gnetol is rapidly glucuronidated and is excreted in urine and via nonrenal routes. Pretreatment of Male NIH Swiss mice (20-35 g) with Gnetol (50mg/kg, SC) is able to increase the latency period to response in analgesia models. |