中文名 | CMI977 |
英文名 | CMI977 |
别名 | 化合物 T14986 |
英文别名 | LDP977 CMI977 175212-04-1 1-[4-[(2S,5S)-5-[(4-fluorophenoxy)methyl]oxolan-2-yl]but-3-ynyl]-1-hydroxyurea Urea, N-[4-[(2S,5S)-5-[(4-fluorophenoxy)methyl]tetrahydro-2-furanyl]-3-butyn-1-yl]-N-hydroxy- |
CAS | 175212-04-1 |
化学式 | C16H19FN2O4 |
分子量 | 322.33 |
密度 | 1.33±0.1 g/cm3(Predicted) |
熔点 | 106-107 °C |
沸点 | 524.8±60.0 °C(Predicted) |
溶解度 | DMSO |
酸度系数 | 10.12±0.50(Predicted) |
存储条件 | -20℃ |
体外研究 | CMI977 is a potent 5-lipoxygenase (5-LO) inhibitor that intervenes in the production of leukotrienes and is presently being developed for the treatment of chronic asthma. It is a single enantiomer with an all-trans (2S,5S) configuration. Of the four isomers of CMI977, the S,S isomer is found to have the best biological activity and is selected for further development. |