Molecular Formula | C16H19FN2O4 |
Molar Mass | 322.33 |
Density | 1.33±0.1 g/cm3(Predicted) |
Melting Point | 106-107 °C |
Boling Point | 524.8±60.0 °C(Predicted) |
Solubility | DMSO |
pKa | 10.12±0.50(Predicted) |
Storage Condition | -20℃ |
In vitro study | CMI977 is a potent 5-lipoxygenase (5-LO) inhibitor that intervenes in the production of leukotrienes and is presently being developed for the treatment of chronic asthma. It is a single enantiomer with an all-trans (2S,5S) configuration. Of the four isomers of CMI977, the S,S isomer is found to have the best biological activity and is selected for further development. |