Overview | Hericium erinaceus polysaccharide is the most important active substance in Hericium erinaceus, and its active part is β(1 → 3) the main chain linked by glycosidic bonds and the branched chain linked by β(1 → 6) glycosidic bonds constitute a glucan. Hericium erinaceus polysaccharide can enhance immune function, remove free radicals and play an anti-aging role, and plays an important role in the regeneration and repair of gastric mucosa epithelium, can enhance the barrier function of gastric mucosa, resist tumor proliferation, resist pathogenic infection, reduce blood glucose concentration in patients with diabetes, anti-microwave radiation, reduce blood lipid concentration and other physiological functions. At the same time, there are protecting liver and liver, strengthening the stomach and spleen, bacteriostasis, anticoagulation, anti-leukopenia, treatment of neurasthenia, body weakness and other diseases, lowering blood fat, anti-thrombosis, promote the growth of mouse adrenal nerve cells and PC12 neurite cells, make neurite outgrowth and other functions. Can be widely used in the field of medicine and health food. |
extraction from Hericium erinaceus | Hericium erinaceus polysaccharide is an effective active ingredient extracted from the fruiting body of Hericium erinaceus. Hericium erinaceus, also known as Hericium erinaceus, Hericium erinaceus, hedgehog, etc., is a famous edible and medicinal fungi in China, known as "the king of mushrooms", and bear palm, Bird's Nest, shark fin and listed as four famous dishes, since ancient times, it has been known as "mountain". Hericium erinaceus is a high-protein, low-fat, rich in minerals and vitamins of excellent food, soft meat, tender and delicious, can help digestion, benefit the five viscera, gastric ulcer, duodenal ulcer and neurasthenia and other specific efficacy, and can improve the body's immunity. Hericium erinaceus contains polysaccharides and polypeptides, which have certain therapeutic and inhibitory effects on tumors in digestive tract. Hericium erinaceus, the fruiting body meat quality, block or head-like, length and width of about 5~15cm. Because of its shape like a monkey head, so called Hericium erinaceus. White when fresh, pale yellow to light brown after drying, narrow base or slightly short stalk, with dense long spines, needle-shaped, 1-3cm in length. Around spines of the seed layer, spores colorless smooth, spherical or nearly spherical, with oil droplets. The entire young part of the fruiting body is edible. Born in the forest oak, walnut and other trees. Distributed in the Northeast, North China, Southwest and other regions. There is cultivation. 1 is Hericium erinaceus polysaccharide extraction method of hot water extraction method, ultrasonic extraction method, enzymatic extraction etc. The optimum technological conditions of traditional hot water extraction method were as follows: solid-liquid ratio 1 ∶ 15, time 2.5h, extraction temperature 80 ℃, extraction times 2: solid-liquid ratio 1: 15, time 20min, extraction temperature 50 C, extraction times 2 times. (2015-10-23) |
structural analysis method | the molecular weight of polysaccharide can be determined by HPLC, TLC, GPC, Sepharose CL-6B gel column chromatography, the monosaccharides and their structures were analyzed by acid hydrolysis, HPLC, TLC, GR, NMR and MS; acid hydrolysis, glycosidase cis-hydrolysis and NMR method were selected as the connecting sequence; Cis-hydrolysis of α-and β-isosteric carbon, NMR method and IR method were used; for the substitution of hydroxyl groups, methods such as methylation reaction-gas chromatography, Periodate Oxidation, NMR, IR and MS were used. The sugar chain-peptide chain linkage mode adopts acid hydrolysis, hydrazine hydrolysis reaction and the like. |
pharmacological action | 1. Improving immunity and anti-tumor anti-cancer is an important biological activity of polysaccharide compounds, which has the characteristics of small toxic and side effects and synergistic effect with chemotherapeutic drugs. Its active moiety is a β(1 → 3)-linked Main chain and β(1 → 6)-linked glucan. The mechanism of action is to increase the phagocytosis of macrophages, promote the formation of immunoglobulin, increase white blood cells, improve the transformation rate of lymphocytes and the body's own disease resistance, and can enhance the body's ability to radiotherapy, resistance to chemotherapy, inhibition of the growth and expansion of cancer cells. 2. The effective rate of anti-ulcer Hericium erinaceus in the treatment of peptic ulcer was 87.2%, the total effective rate in the treatment of chronic gastritis was 96.3%, the total effective rate of stomach and ulcer was 94.4%, and the total effective rate of duodenal ulcer was 92.7%. The mechanism of action is that the amino acids and polysaccharides of Hericium erinaceus play an important role in the regeneration and repair of gastric mucosa epithelium, and can enhance the barrier function of gastric mucosa. At the same time, Hericium erinaceus has a good therapeutic effect on bloating, belching, pantothenic acid, fecal occult blood, loss of appetite and so on. 3. Anti-aging polysaccharide can enhance immune function, remove free radicals and play an anti-aging role. Hericium erinaceus polysaccharide can increase SOD activity in brain and liver of mice, significantly reduce the content of myocardial lipofuscin in Drosophila and mice, enhance the flying ability of Drosophila, and has anti-aging and anti-fatigue effects. 4. Hypoglycemic more than 80 kinds of polysaccharides extracted from fungi and other Chinese herbal medicines can significantly reduce the blood glucose concentration of the experimental animal model of hyperglycemia. Hericium erinaceus polysaccharide can significantly reduce blood glucose concentration, and the serum triglyceride and total cholesterol content has obvious effect. Anti-radiation Hericium erinaceus polysaccharide also has the function of anti-microwave radiation, and its protective mechanism may be related to its improvement of immune function, enhancement of immune regulation and protection of hematopoietic tissue. 6. Other functions of Hericium fungi are liver protection, liver, stomach and spleen, antibacterial, anticoagulant, anti-leukopenia, treatment of neurasthenia, body weakness and other diseases, lowering blood lipids, anti-thrombosis, promote the growth of mouse adrenal nerve cells and PC12 neurite cells, make neurite outgrowth and other functions. |
Use | effect of lowering blood glucose and lipid |