sulfopin
2-chloro-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-neopentylacetamide
CAS: 2451481-08-4
Molecular Formula: C11H20ClNO3S
sulfopin - Names and Identifiers
sulfopin - Physico-chemical Properties
| Molecular Formula | C11H20ClNO3S |
| Molar Mass | 281.8 |
| Density | 1.23±0.1 g/cm3(Predicted) |
| Boling Point | 455.5±45.0 °C(Predicted) |
| Solubility | DMSO : 50 mg/mL |
| Appearance | solid |
| Color | Off-white |
| pKa | -1.36±0.20(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| Use | Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo. Sulfopin is highly selective, as validated by two independent chemoproteomics methods, achieves potent cellular and in vivo target engagement and phenocopies Pin1 genetic knockout. Sulfopin induced downregulation of c-Myc target genes, reduced tumor progression and conferred survival benefit in murine and zebrafish models of MYCN-driven neuroblastoma, and in a murine model of pancreatic cancer. Sulfopin is a chemical probe suitable for assessment of Pin1-dependent pharmacology in cells and in vivo, and that Pin1 warrants further investigation as a potential cancer drug target. |
sulfopin - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 0 ml | 0 ml | 0 ml |
| 5 mM | 0 ml | 0 ml | 0 ml |
| 10 mM | 0 ml | 0 ml | 0 ml |
| 5 mM | 0 ml | 0 ml | 0 ml |
Last Update：2024-01-02 23:10:35
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Product Name: 2-chloro-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-neopentylacetamide Visit Supplier Webpage Request for quotation
CAS: 2451481-08-4
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CAS: 2451481-08-4
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View History
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