phosgenated

phosgenated - Names and Identifiers

Name	4,4'-dihydroxy-7,7'-ureylenedi(naphthalene-2-sulphonic acid
Synonyms	Bis-J Acid J Acid Urea phosgenated 6,6'-ureylenbis-1-naphthol-3-sulfonic acid N,N'-Bis[6-(1-naphthol-3-sulfonic acid)]urea 6,6'-ureylene-bis(1-naphthol-3-sulfonic acid) 5,5-DIHYDROXY-7,7-DISULPHO-2,2-DINAPHTHYL UREA N,N'-bis(4-hydroxy-2-sulfonaphthalene-7-yl)urea 7,7'-Ureylenebis(4-hydroxy-2-naphthalenesulfonic acid) 7,7'-Ureylene-bis-(4-hydroxynaphthalene-2-sulfonic acid) 4,4'-dihydroxy-7,7'-ureylenedi(naphthalene-2-sulphonic acid 4,4'-dihydroxy-7,7'-ureylenedi(naphthalene-2-sulphonic acid) 7,7-(carbonyldiimino)bis[4-hydroxy-2-naphthalenesulfonic acid] 2-Naphthalenesulfonic acid, 7,7-(carbonyldiimino)bis4-hydroxy- 7,7'-(Carbonyldiimino)bis[4-hydroxy-2-naphthalenesulfonic acid] 4-hydroxy-7-{[(5-hydroxy-7-sulfonaphthalen-2-yl)carbamoyl]amino}naphthalene-2-sulfonic acid
CAS	134-47-4
EINECS	205-142-9
InChI	InChI=1/C21H16N2O9S2/c24-19-9-15(33(27,28)29)7-11-5-13(1-3-17(11)19)22-21(26)23-14-2-4-18-12(6-14)8-16(10-20(18)25)34(30,31)32/h1-10,24-25H,(H2,22,23,26)(H,27,28,29)(H,30,31,32)

phosgenated - Physico-chemical Properties

Molecular Formula	C21H16N2O9S2
Molar Mass	504.49
Density	1.798±0.06 g/cm3(Predicted)
Melting Point	86-88 ℃
Appearance	Dry gray-white powder
pKa	-0.17±0.40(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.822
Use	As an intermediate for azo dyes, used in the manufacture of direct Orange S, direct acid fast red 4BS, etc

phosgenated - Reference Information

EPA chemical information	Information provided by: ofmpub.epa.gov (external link)
Biological activity	AMI-1 free acid is an effective, cell-permeable, reversible protein arginine N-methyltransferase (PRMTs) inhibitor, The IC50 values for human PRMT1 and yeast Hmt1p are 8.8 μM and 3.0 μM respectively. AMI-1 free acid exerts an inhibitory effect on PRMTs by blocking peptide-substrate binding.
Target	Value
HMT ()
human PRMT1 ()
yeast Hmt1p (Cell-free assay)	3.0 μM
Cell Line:	S180 cells, U2OS cells S180 cells
Concentration:	0.6 mM, 1.2 mM, 2.4 mM 1.2 mM, 2.4 mM
Incubation Time:	48 hours, 72 hours, 96 hours 48 hours, 72 hours
Result:	Inhibited the cell viability. Increased the percentages of cells undergoing apoptosis. Decreased tumor weight.
Animal Model:	6-7 weeks old male Kunming mice (18-22 g), with S180 cells xenograft
Dosage:	0.5 mg
Administration:	Intratumorally, daily, for 7 days
use	is an intermediate for azo dyes, used to make direct orange s, direct acid-resistant red 4BS, etc.

Last Update：2024-04-10 22:29:15

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View History

phosgenated
Isovaleric acid isoamyl ester
54375-47-2

phosgenated

4,4'-dihydroxy-7,7'-ureylenedi(naphthalene-2-sulphonic acid

CAS: 134-47-4

Molecular Formula: C21H16N2O9S2

phosgenated - Names and Identifiers

phosgenated - Physico-chemical Properties

phosgenated - Reference Information

Supplier List

phosgenated Request for Quotation

4,4'-dihydroxy-7,7'-ureylenedi(naphthalene-2-sulphonic acid

CAS: 134-47-4

Molecular Formula: C21H16N2O9S2

phosgenated - Names and Identifiers

phosgenated - Physico-chemical Properties

phosgenated - Reference Information

Supplier List

phosgenated