amital
amobarbital
CAS: 57-43-2
Molecular Formula: C11H18N2O3
amital - Names and Identifiers
amital - Physico-chemical Properties
| Molecular Formula | C11H18N2O3 |
| Molar Mass | 226.27 |
| Density | 1.1376 (rough estimate) |
| Melting Point | 156-158°C |
| Boling Point | 367.89°C (rough estimate) |
| Flash Point | 9℃ |
| Water Solubility | <0.1 g/100 mL at 18.5 ºC |
| Color | Slightly bitter crystals or leaflets from water oralc |
| pKa | 8.0(at 25℃) |
| Storage Condition | -20°C |
| Stability | Stable. Incompatible with strong oxidizing agents. Hygroscopic. |
| Refractive Index | 1.4620 (estimate) |
| Physical and Chemical Properties | White crystalline powder. Odorless. The taste was slightly bitter. The melting point was 155-158.5 °c. Slightly soluble in cold water, slightly soluble in ethanol, ether, soluble in alkaline solution. The aqueous solution was weakly acidic. Moderate to moderate barbiturate hypnotics. |
| Use | Mainly used for sedation, hypnosis, anticonvulsant. |
amital - Risk and Safety
| Risk Codes | R11 - Highly Flammable R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R39/23/24/25 - |
| Safety Description | S16 - Keep away from sources of ignition. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | 3249 |
| WGK Germany | 1 |
| HS Code | 2933530000 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 in mice (mg/kg): 212 s.c. (Irrgang) |
amital - Standard
Authoritative Data Verified Data
This product is 5-ethyl-5-(3-methylbutyl)-2,4,6(1H,3H,5h)-pyrimidinetrione. Calculated as dried product, the content of C11H18N203 shall not be less than 98.5%.
Last Update：2024-01-02 23:10:35
amital - Trait
Authoritative Data Verified Data
- This product is white crystalline powder; Odorless.
- This product is soluble in ethanol or ether, dissolved in chloroform, very slightly dissolved in water; Dissolved in sodium hydroxide or sodium carbonate solution.
melting point
The melting point of this product (General rule 0612 first method) is 157~160°C.
Last Update：2022-01-01 11:54:28
amital - Differential diagnosis
Authoritative Data Verified Data
- This product shows the identification reaction of malonylurea (General rule 0301).
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 163).
Last Update：2022-01-01 11:54:29
amital - Exam
Authoritative Data Verified Data
clarity of alkaline solution
take l.Og of this product, add 10ml of sodium hydroxide solution to dissolve, the solution should be clarified.
chloride
take about 0.30g of this product, add 30ml of water, boil for 2 minutes, let it cool, filter, add an appropriate amount of water on the filter to make the filtrate 50ml, shake well, take 25ml, inspection according to law (General rule 0801), compared with the standard sodium chloride solution 7.0ml of the control solution, not more concentrated (0.047%).
Related substances
take an appropriate amount of this product, add the mobile phase to dissolve and dilute to make a solution containing about 1 mg per 1ml as a test solution; Take 1ml for precision measurement and put it in a 200 measuring flask, dilute to the scale with the mobile phase, shake, and serve as a control solution. According to the test of high performance liquid chromatography (General 0512), silica gel was bonded with eighteen alkyl silane as filler; 0.02 mol / L potassium dihydrogen phosphate solution (adjusted to pH 3.0±0.1 with phosphoric acid)-acetonitrile (65:35) is mobile phase, and the detection wavelength is 220mn; The number of theoretical plates is not less than 2500 according to the calculation of amobarbital peak, and the separation degree of amobarbital peak and adjacent impurity peaks shall meet the requirements. 5ul of the control solution and 5ul of the test solution were injected into the liquid chromatograph respectively, and the chromatogram was recorded to 5 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (0.5%).
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 1.0% (General rule 0831).
ignition residue
not more than 0.1% (General rule 0841).
Last Update：2022-01-01 11:54:30
amital - Content determination
Authoritative Data Verified Data
take this product about 0.2g, precision weighing, add methyl alcohol 40ml to dissolve, and then add a new anhydrous sodium carbonate solution 15ml, according to the potential titration method (General rule 0701), with silver nitrate titration solution (0.lmol/L) titration. Each 1 ml of the silver nitrate titration solution (0.1 mol/L) corresponds to 22.63mg of C11H18N203.
Last Update：2022-01-01 11:54:30
amital - Category
Authoritative Data Verified Data
hypnotic drugs, anticonvulsants.
Last Update：2022-01-01 11:54:30
amital - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 11:54:30
amital - Amobarbital tablets
Authoritative Data Verified Data
This product contains Amobarbital (C11H18N203) should be 94.0% to 106.0% of the label.
trait
This product is white tablet.
identification
take an appropriate amount of fine powder of this product (about 0.5g of amobarbital), add 10ml of sodium carbonate test solution, dissolve the amobarbital at a slight temperature, filter, drop hydrochloric acid into the filtrate until the precipitate is complete, filter; the precipitate is washed with water, dried at l05 °C, and then measured according to law (General Principles 0612 first method), and the melting point is 155~158.5°C; the remaining precipitates show the identification reaction of malonylureas (General rule 0301).
examination
- relevant substances: take an appropriate amount of the fine powder of this product, add the mobile phase to dissolve and dilute to prepare a solution containing about 1 mg of amobarbital per 1ml, filter, and take the continued filtrate as the test solution; take 1ml of precision, 100ml flask, diluted with mobile phase to scale, shake, as a control solution. The assay was performed according to the method for related substances of amobarbital. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%).
- dissolution the dissolution of this product was determined according to the dissolution and release determination method (General rule 0931, the first method), and the phosphate buffer (pH 7.6) was used as the dissolution medium, and the rotation speed was 100 rpm, operate in accordance with the law, after 30 minutes, take 10ml of the solution for filtration, take 5ml of the filtrate with precision, put it in a 25ml measuring flask, dilute it to the standard with dissolution medium, and shake well, precision weighing, dissolving and quantitatively diluting with dissolution medium to prepare a solution containing about 35ug per 1 ml. The absorbance of each of the above two Solutions was measured at a wavelength of 0401 nm by ultraviolet-visible spectrophotometry (general), and the elution amount of each tablet was calculated. The limit is 70% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
Take 20 tablets of this product, precision weighing, fine grinding, precision weighing 3 (about 0.2g equivalent to amobarbital), add methanol 40ml to make amobarbital solution, according to the method under the item of amobarbital, from "add new 3% anhydrous sodium carbonate solution 15ml", according to the law. Each 1 ml of silver nitrate titration solution (0.1 mol/L) corresponds to 22.63mg of C11H18N203.
category
Same as amobarbital.
specification
O.lg
storability
sealed storage.
Last Update：2022-01-01 11:54:31
