148-18-5
ditiocarb sodium
CAS: 148-18-5
Molecular Formula: C5H10NNaS2
148-18-5 - Names and Identifiers
| Name | ditiocarb sodium |
| Synonyms | NaDDTC ditiocarb sodium Sodium diethyldithiocarbamate Sodium Diethyl Dithiocarbamate sodium diethylcarbamodithioate sodium carbamodithioate - butane |
| CAS | 148-18-5 |
| EINECS | 205-710-6 |
| InChI | InChI=1/C4H10.CH3NS2.Na/c1-3-4-2;2-1(3)4;/h3-4H2,1-2H3;(H3,2,3,4);/q;;+1/p-1 |
148-18-5 - Physico-chemical Properties
| Molecular Formula | C5H10NNaS2 |
| Molar Mass | 171.26 |
| Density | 1.1000 |
| Melting Point | 95℃ |
| Boling Point | 176.4℃ at 760mmHg |
| Water Solubility | >=10 g/100 mL at 14℃ |
| Appearance | Form Liquid, Color Clear, colorless |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Physical and Chemical Properties | Chemical properties trihydrate: thin and irregular flake crystals obtained from acetone, melting point 94~102 ℃; The melting point is also reported to be 90~92 ℃. Easily soluble in water, soluble in ethanol, methanol or acetone, insoluble in ether or benzene. The aqueous solution is alkaline and slowly decomposes. UV maximum absorption (ethanol):257,290nm(ε1200,13000). Acute toxicity LD50 rats, mice (mg/kg):2830,1870 oral; Mice:>1000 intravenous injection. |
| Use | The use of low molecular sulfide immune enhancer can promote the maturation of T cells, increase the total amount of T4 cells and improve the function of natural killer cells, and has a synergistic effect with zidovudine. For AIDS. |
148-18-5 - Risk and Safety
| UN IDs | 3077 |
| Hazard Class | 9 |
| Packing Group | III |
148-18-5 - Upstream Downstream Industry
148-18-5 - Reference
| Reference Show more | 1. Liu Qiumei, Tian Weiwei, Yu Guangyi, et al. Pre-column Derivatization-HPLC Determination of Pharmacokinetic Parameters of Bucucurfan in Rabbits [J]. Modern Applied Pharmacy in China, 35(9). 2. [IF = 6.165] Yang Wang et al."Synthesis of Fe3O4 @ SiO2-PHEMA via redox of H2O2 and Fe2 for efficient removal of Cu2 from aqueous solution." J Mol Liq. 2019 Dec;296:111865 |
148-18-5 - Preparation Method
Open Data Verified Data
dissolve diethanolamine in methanol, add carbon disulfide methanol solution, drop 40% sodium hydroxide methanol solution, filter out the precipitated crystals, wash with methanol for 3-4 times, and then recrystallize with methanol, after drying, pure Sodium diethyldithiocarbamate was obtained.
Last Update：2025-06-10 22:55:16
148-18-5 - Safety
Open Data Verified Data
rat, mouse oral LD50;2830mg/kg, 1870mg/kg; Mouse intravenous injection LD50: >lOOOmg/kg. Staff should be protected. If the eyes and skin are touched, they should be immediately rinsed with plenty of flowing water. The working environment should be well ventilated. Mixing with oxidant and edible chemicals is strictly prohibited.
Last Update：2022-01-01 09:26:10
148-18-5 - Security information
| toxic substance data | 148-18-5(Hazardous Substances Data) |
Last Update：2024-04-10 22:29:15
148-18-5 - Nature
| Solubility | about 35 % in water, less soluble in organic solvents. However, the free acid, diethyldithiocarbamic acid, is readily soluble in organic solvents and less soluble in water. Thus, on acidification of an aqueous solution of a diethyldithiocarbamate, the free acid can be extracted with chloroform or carbon tetrachloride. The distribution ratio is 2,360 for chloroform and 343 for carbon tetrachloride. |
| Specific gravity | 1.08 |
| Hydrolytic sensitivity | 0: forms stable aqueous solutions |
| (IARC) Carcinogen Classification | 3 (Vol. 12, Sup 7) 1987 |
| EPA chemical information | Sodium diethyldithiocarbamate (148-18-5) |
Last Update：2024-04-09 19:04:56
148-18-5 - Uses and synthesis methods
application
Copper reagent is used in the color reaction of copper, used as a precipitant and solvent extractant for soft metal ions, and also used as a photometric reagent for the determination of metals such as bismuth, copper, and nickel.
Test example
Applicability test for copper
measure 1.0 mL of sample solution (4.3.1) after water dissolution test and dilute to 10mL.
measure 1.0 mL of copper impurity standard solution (1 mL of Luo solution contains 0.001 mgCu), place it in a separatory funnel, add 0.5 mL of ammonia solution (10%), and dilute it to 20mL. Add 1.0 mL of the diluted sample volume and 5.0 mL of isoamyl alcohol, shake for 1min, and place. At the same time, a blank test was made. The organic layer should be yellow, which is obviously different from the blank test solution.
Determination of impurities
the sample must be weighed to 0.01g.
1 water dissolution test
weigh 0.5g of sample and put it in 25mL of water. the liquid volume should be clear and free of mechanical impurities (the liquid volume of this sample should be retained for determination of copper applicability test).
2 burn residue
weigh 1 g of sample, place it in the ground light with constant weight at 650±50 ℃, slowly heat it until carbonization and cooling, moisten the residue with 1mL sulfuric acid, continue heating until sulfuric acid vapor escapes, and burn it to constant weight in a high temperature furnace at 650±50 ℃.
The residue content is calculated according to the following formula:
x =m1/m×100
formula: x-percentage content of residue,%;
m1 mass of residue after burning, g;
m-sample mass, g.
biological activity
Ditiocarb sodium (Sodium diethyldithiocarbamate) is a copper reagent, which reacts with Cu2 + solution to form a complex, which improves the precipitation rate of copper replacement. Sodium diethyldithiocarbamate can reduce HIV infection.
Target
HIV
in vitro studies
Ditiocarb sodium (Sodium diethyldithiocarbamate) reacts with the Cu 2+ solution giving a complex of copper diethyldithiocarbamate, which enhances the rate of cementation. Ditiocarb sodium is an agent with strong antioxidant capacity and chelating activities.
In vivo studies
Ditiocarb sodium (Sodium diethyldithiocarbamate) improves the depressed immune responses of newborn and aged mice. Sodium diethyldithiocarbamate prevents cisplatin nephrotoxicity in animals without reducing the antitumor activity. In that AIDS model, Ditiocarb sodium reduces lymphadenopathy and hypergammaglobulinemia, restores immunocompetence, and prolongs survival.
chemical properties
trihydrate: thin and irregular flake crystals obtained from acetone, melting point 94~102 ℃; Melting point 90~92 ℃ has also been reported. Easily soluble in water, soluble in ethanol, methanol or acetone, insoluble in ether or benzene. The aqueous solution is alkaline and slowly decomposes. UV maximum absorption (ethanol):257,290nm(& epsilon;1200,13000). Acute toxic LD50 rats, mice (mg/kg):2830,1870 oral; Mice:>1000 intravenous injection.
Use low molecular sulfide immune enhancer can promote the maturation of T cells, increase the total amount of T4 cells and improve the function of natural killer cells. It has a synergistic effect with zidovudine. For AIDS
Last Update：2024-04-09 21:01:54
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View History
148-18-5
Decafluorobiphenyl
65052-63-3
69398-48-7
m-terphenyl-2'-ol
21302-43-2
31396-35-7
Melissyl alcohol
DL-瓜氨酸
51246-94-7
Decafluorobiphenyl
65052-63-3
69398-48-7
m-terphenyl-2'-ol
21302-43-2
31396-35-7
Melissyl alcohol
DL-瓜氨酸
51246-94-7
Raw Materials for 148-18-5
Downstream Products for 148-18-5
Acetonitrile
ORNOPROSTIL
noncyanide zinc plating additive-TDAE
DIETHYL DITHIOBIS(THIONOFORMATE)
methyl diethyldithiocarbamate
Sodium ethylxanthogenate
ORNOPROSTIL
noncyanide zinc plating additive-TDAE
DIETHYL DITHIOBIS(THIONOFORMATE)
methyl diethyldithiocarbamate
Sodium ethylxanthogenate