SD-169
1H-indole-5-carboxamide
CAS: 1670-87-7
Molecular Formula: C9H8N2O
SD-169 - Names and Identifiers
| Name | 1H-indole-5-carboxamide |
| Synonyms | SD-169 5-CarbaMoylindole 1H-indole-5-carboxamide 5-(AMinocarbonyl)-1H-indole 1H-Indole-5-carboxamide(9CI) p38 MAP Kinase Inhibitor VII, SD-169 5-(Aminocarbonyl)-1H-indole, 5-Carbamoylindole, 5-Carboxamidoindole 5-(Aminocarbonyl)-1H-indole, 5-Carbamoylindole, 5-Carboxamidoindole |
| CAS | 1670-87-7 |
| InChI | InChI=1/C9H8N2O/c10-9(12)7-1-2-8-6(5-7)3-4-11-8/h1-5,11H,(H2,10,12) |
SD-169 - Physico-chemical Properties
| Molecular Formula | C9H8N2O |
| Molar Mass | 160.17 |
| Density | 1.328±0.06 g/cm3(Predicted) |
| Melting Point | 159-163°C |
| Boling Point | 457.6±18.0 °C(Predicted) |
| Flash Point | 230.563°C |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Off-white solid |
| Color | Off-White to Light Purple |
| pKa | 16.25±0.30(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.717 |
| Physical and Chemical Properties | Storage Conditions: 2-8 ℃ |
| In vitro study | SD-169 significantly reduces p38 and HSP60 expression in T cells of the pancreatic beta islets. SD-169 demonstrates 38-fold potency against p38α MAP kinase (IC 50 =3.2 nM) than p38β MAP kinase (IC 50 =122 nM). |
SD-169 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
SD-169 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 6.243 ml | 31.217 ml | 62.434 ml |
| 5 mM | 1.249 ml | 6.243 ml | 12.487 ml |
| 10 mM | 0.624 ml | 3.122 ml | 6.243 ml |
| 5 mM | 0.125 ml | 0.624 ml | 1.249 ml |
Last Update：2024-01-02 23:10:35
SD-169 - Reference Information
| biological activity | SD-169 is an ATP competitive MAPK p38α inhibitor with oral activity, and its IC50 value is 3.2 nM. SD-169 also has a weak inhibitory effect on p38βMAPK, and its IC50 value is 122 nM. SD-169 prevent the development of diabetes by inhibiting the infiltration and activation of T cells. |
Last Update：2024-04-09 20:52:54
Supplier List
Spot supply
Product Name: 1H-indole-5-carboxamide Request for quotationCAS: 1670-87-7
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: SD-169 Visit Supplier Webpage Request for quotationCAS: 1670-87-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: SD-169 Visit Supplier Webpage Request for quotationCAS: 1670-87-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: SD-169 (Standard) Visit Supplier Webpage Request for quotationCAS: 1670-87-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: 1H-INDOLE-5-CARBOXAMIDE Visit Supplier Webpage Request for quotation
CAS: 1670-87-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1670-87-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: 1H-indole-5-carboxamide Request for quotationCAS: 1670-87-7
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: SD-169 Visit Supplier Webpage Request for quotationCAS: 1670-87-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: SD-169 Visit Supplier Webpage Request for quotationCAS: 1670-87-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: SD-169 (Standard) Visit Supplier Webpage Request for quotationCAS: 1670-87-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: 1H-INDOLE-5-CARBOXAMIDE Visit Supplier Webpage Request for quotation
CAS: 1670-87-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1670-87-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
SD-169
Samarium chloride hexahydrate
Phosphinic acid aluminum salt
1439-07-2
URB754
Diammonium chromate
76-89-1
4191-73-5
草酸錳
MCF
Samarium chloride hexahydrate
Phosphinic acid aluminum salt
1439-07-2
URB754
Diammonium chromate
76-89-1
4191-73-5
草酸錳
MCF