PYRIMIDIN-2-AMINE
2-Aminopyrimidine
CAS: 109-12-6
Molecular Formula: C4H5N3
PYRIMIDIN-2-AMINE - Names and Identifiers
| Name | 2-Aminopyrimidine |
| Synonyms | 2-pyridiylamine 2-Aminopyrimide 2-Pyrimidinamine 2-Pyrimidinemine PYRIMIDIN-2-AMINE 2-Aminopyrimidine pyrimidin-2-amine 2-amino-pyrimidin PYRIMIDIN-2-YLAMINE TIMTEC-BB SBB004387 2-Amino-1,3-diazine Aminopyrimidine, 2- pyrimidin-2-ylamine pyrimidin-2-amine analogue 1,2-dihydro-2-imine-pyrimidin |
| CAS | 109-12-6 |
| EINECS | 203-648-4 |
| InChI | InChI=1/C4H5N3/c5-4-6-2-1-3-7-4/h1-3H,(H2,5,6,7) |
| InChIKey | LJXQPZWIHJMPQQ-UHFFFAOYSA-N |
PYRIMIDIN-2-AMINE - Physico-chemical Properties
| Molecular Formula | C4H5N3 |
| Molar Mass | 95.1 |
| Density | 1.1031 (rough estimate) |
| Melting Point | 122-126 °C (lit.) |
| Boling Point | 158 °C (139.5186 mmHg) |
| Flash Point | 103 °C |
| Water Solubility | SOLUBLE |
| Solubility | Easily soluble in water, alcohol, acetone and chloroform, slightly soluble in ether and benzene. Easy to sublimate. |
| Vapor Presure | 0.00521mmHg at 25°C |
| Appearance | Colorless crystal |
| Color | White to light yellow |
| BRN | 107014 |
| pKa | 3.45(at 20℃) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.5200 (estimate) |
| MDL | MFCD00006089 |
| Physical and Chemical Properties | Melting point 124-127°C boiling point 158 ° C (186 mmHg) flash point 103°C water-SOLUBLE solution |
| Use | Used as a pharmaceutical Intermediate |
PYRIMIDIN-2-AMINE - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
| UN IDs | UN 2811 |
| WGK Germany | 3 |
| RTECS | UV6326000 |
| FLUKA BRAND F CODES | 8 |
| TSCA | Yes |
| HS Code | 29335995 |
PYRIMIDIN-2-AMINE - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Uses | Used in organic synthesis, as pharmaceutical intermediates and biochemical reagents. Used as a pharmaceutical intermediate |
| Production method | Using furochloric acid and guanidine nitrate as raw materials, it is obtained by cyclization, decarboxylation and dechlorination. The methanol solution of sodium methoxide and guanidine nitrate were added and filtered within 30min at 40-45 ℃ to obtain the methanol solution of free guanidine. This solution is added into a reaction tank, furfuric acid-methanol solution is added within 95 ℃ for 30min, after addition, heat preservation at 60±1 ℃ for 40min, decompression distillation is carried out, methanol is distilled to a certain amount, distillation is stopped, reactants are dissolved in water, acidified with 30% hydrochloric acid to pH = 1 at 30-35 ℃, filtered and washed with water, and dried at 95 ℃ to obtain crude cyclists. The crude cyclidine is placed in a sublimator, and decarboxylated and sublimated at 150-300 ℃ to obtain 2-amino -5-chloridine [5428-89-7]. The yield of cyclization and decarboxylation is about 67.5%. Isopropanol, water caustic soda, zinc mud, (zinc hydroxide 60%), 2-amino -5-chloropyrimidine and zinc powder are added to the reaction tank. After reflux at 77-80 ℃ for 8 hours, low boiling point distillate is recovered first, and isopropanol is recovered at 77-100 ℃. Cold to 77-85 ℃ and filter, wash the filter cake with hot water. The filtrate and part of the lotion are combined, granular caustic soda is added, and alkali is analyzed below 50 ℃ for 1h. Extract with formaldehyde ester below 70 ℃, separate the jelly, adjust the pH = 7.5-8 with hydrochloric acid, then separate the oil, and then recover the formaldehyde ester to precipitate 2-aminopyrimidine. The finished product was dried at 40-50 ℃ with a yield of 85.7%. Another method is to react with guanidine hydrochloride and propargaldehyde. Add 90ml concentrated hydrochloric acid to a 300ml three-mouth flask equipped with a thermometer, a dropping funnel and a stirrer, and cool the outside with an ice salt bath. Under stirring condition, 27g of guanidine hydrochloride with a purity of about 80% is added below 10 ℃. After the carbon dioxide is released, it is cooled to 0 ℃, and 11.1g of crude propargaldehyde (8.7g of pure product) is dripped. When dripping, the reaction temperature will rise accordingly, but the control shall not exceed 20 ℃. After the exotherm of the reaction is stopped, it is placed overnight at room temperature, then the reaction liquid is moved into a distillation flask, evaporated and concentrated under reduced pressure at about 35°C, and after cooling, 60ml of 30% sodium hydroxide solution is added to precipitate the product 2-aminopyrimidine. The substance is extracted with 1500ml benzene at 60-70 ℃, and the benzene solution is cooled and dried with calcium chloride. Distillation removes benzene to obtain 10.2-10.7g of product with a yield of 66.5%-70%. Melting point 125-127 ℃. |
Last Update：2024-04-09 21:11:58
Supplier List
Featured ProductsSpot supply
Product Name: 2-Aminopyrimidine Visit Supplier Webpage Request for quotationCAS: 109-12-6
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: 2-Aminopyrimidine Request for quotationCAS: 109-12-6
Tel: 021-60556179
Email: 18721521379@163.com
Mobile: +86-18721521379
Wechat: 18721521379
Product Name: 2-Aminopyrimidine Request for quotation
CAS: 109-12-6
Tel: 0513-66814854
Email: pules.cn@gmail.com
Mobile: +86-17551318830
CAS: 109-12-6
Tel: 0513-66814854
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Spot supply
Product Name: 2-Aminopyrimidine Request for quotationCAS: 109-12-6
Tel: +86-13776910623
Email: r@reformchem.com
Mobile: +86-13776910623
QQ: 3785839865
Wechat: chemical6666
Multiple SpecificationsSpot supply
Product Name: 2-Aminopyrimidine Request for quotationCAS: 109-12-6
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: 2-Aminopyrimidine Visit Supplier Webpage Request for quotationCAS: 109-12-6
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: 2-Aminopyrimidine Visit Supplier Webpage Request for quotationCAS: 109-12-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: 2-Aminopyrimidine Visit Supplier Webpage Request for quotationCAS: 109-12-6
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: 2-Aminopyrimidine Request for quotation
CAS: 109-12-6
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 109-12-6
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Spot supply
Product Name: 2-Aminopyrimidine Visit Supplier Webpage Request for quotationCAS: 109-12-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: 2-Aminopyrimidine Visit Supplier Webpage Request for quotationCAS: 109-12-6
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: 2-Aminopyrimidine Request for quotationCAS: 109-12-6
Tel: 021-60556179
Email: 18721521379@163.com
Mobile: +86-18721521379
Wechat: 18721521379
Product Name: 2-Aminopyrimidine Request for quotation
CAS: 109-12-6
Tel: 0513-66814854
Email: pules.cn@gmail.com
Mobile: +86-17551318830
CAS: 109-12-6
Tel: 0513-66814854
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Spot supply
Product Name: 2-Aminopyrimidine Request for quotationCAS: 109-12-6
Tel: +86-13776910623
Email: r@reformchem.com
Mobile: +86-13776910623
QQ: 3785839865
Wechat: chemical6666
Multiple SpecificationsSpot supply
Product Name: 2-Aminopyrimidine Request for quotationCAS: 109-12-6
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: 2-Aminopyrimidine Visit Supplier Webpage Request for quotationCAS: 109-12-6
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: 2-Aminopyrimidine Visit Supplier Webpage Request for quotationCAS: 109-12-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: 2-Aminopyrimidine Visit Supplier Webpage Request for quotationCAS: 109-12-6
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: 2-Aminopyrimidine Request for quotation
CAS: 109-12-6
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 109-12-6
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Spot supply
Product Name: 2-Aminopyrimidine Visit Supplier Webpage Request for quotationCAS: 109-12-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History