Name | OGL002 |
Synonyms | OGL002 CS-830 OGL-002 OG-L002 OG L002 4'-((1R,2S)-2-Aminocyclopropyl)biphenyl-3-ol 4'-((1R,2S)-2-Aminocyclopropyl)-[1,1'-biphenyl]-3-ol [1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]-4'-((1R,2S)-2-Aminocyclopropyl)biphenyl-3-o OG-L002 4'-((1S,2R)-2-aminocyclopropyl)-[1,1'-biphenyl]-3-ol 3-[4-[(1R,2S)-2-aminocyclopropyl]phenyl]phenol OG-L002 [1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]- |
CAS | 1357302-64-7 |
Molecular Formula | C15H15NO |
Molar Mass | 225.29 |
Density | 1.193±0.06 g/cm3(Predicted) |
Boling Point | 416.7±45.0 °C(Predicted) |
pKa | 9.78±0.10(Predicted) |
Storage Condition | -20℃ |
In vitro study | OG-L002 effectively inhibited the expression of HSV IE gene in HeLa cells and HFF cells, and the IC50 was about 10 μm and 3 μm respectively. In either HeLa cells or HFF cells, OG-L002(50 μm) resulted in a decrease in the yield of progeny Virus, but without significant toxicity. OG-L002(50 μm) increased the level of inhibitory chromatin on the Virus IE gene promoter. In addition, OG-L002 also inhibited the expression of human Cytomegalovirus IE gene and Adenovirus E1A gene. |
In vivo study | In a mouse model, OG-L002 (6 to 40 mg/kg) inhibited HSV primary infection in a dose-dependent manner. In addition, OG-L002 also inhibited the delay of activation by Herpes Sinplex Virus in the mouse ganglion explant model. |