| Molecular Formula | C15H15NO |
| Molar Mass | 225.29 |
| Density | 1.193±0.06 g/cm3(Predicted) |
| Boling Point | 416.7±45.0 °C(Predicted) |
| pKa | 9.78±0.10(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | OG-L002 effectively inhibited the expression of HSV IE gene in HeLa cells and HFF cells, and the IC50 was about 10 μm and 3 μm respectively. In either HeLa cells or HFF cells, OG-L002(50 μm) resulted in a decrease in the yield of progeny Virus, but without significant toxicity. OG-L002(50 μm) increased the level of inhibitory chromatin on the Virus IE gene promoter. In addition, OG-L002 also inhibited the expression of human Cytomegalovirus IE gene and Adenovirus E1A gene. |
| In vivo study | In a mouse model, OG-L002 (6 to 40 mg/kg) inhibited HSV primary infection in a dose-dependent manner. In addition, OG-L002 also inhibited the delay of activation by Herpes Sinplex Virus in the mouse ganglion explant model. |