Ionomycin
Ionomycin (free acid)
CAS: 56092-81-0
Molecular Formula: C41H72O9
Ionomycin - Names and Identifiers
Ionomycin - Physico-chemical Properties
| Molecular Formula | C41H72O9 |
| Molar Mass | 709.01 |
| Density | 1.072±0.06 g/cm3(Predicted) |
| Melting Point | 204℃-206℃ |
| Boling Point | 817.2±65.0 °C(Predicted) |
| Solubility | Soluble to 10 mM in Ethanol and to 10 mM in DMSO |
| Appearance | Morphological Waxy solid |
| Color | Yellow |
| BRN | 3642126 |
| pKa | 4.77±0.10(Predicted) |
| Storage Condition | −20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| Sensitive | Sensitive to light |
| MDL | MFCD06798385 |
| Physical and Chemical Properties | Bioactive Ionomycin (SQ23377) is an effective and selective calcium ionophore (calcium ionophore) and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr = Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin (SQ23377) also induces protein kinase C (PKC) activation. |
| Use | Ionomycin is more effective than A23187 as a Ca ionophore. Ionomycin is used in research on Ca transport across biological membranes; Ionomycin induces apoptotic degeneration of embryonic cortical neurons |
| In vitro study | Ionomycin is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus . Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca 2+ concentration from 50 to 180 nM. DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Necrosis could be detected in ~1-5% of the Ionomycin treated cells. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment. Ionomycin-mediated cleavage and exosome release. Following Ionomycin exposure, medium conditioned by SKOV3ip cells had increased amounts of exosomes containing the L1-32 cleavage fragment. |
Ionomycin - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S36 - Wear suitable protective clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S27 - Take off immediately all contaminated clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | NO0650000 |
| FLUKA BRAND F CODES | 8-10 |
| HS Code | 29419090 |
| Hazard Class | 3 |
Ionomycin - Reference
| Reference Show more | 1. Luo Yuan Tang Lan Liao Chunshu. The level and significance of Th9/Th17 in peripheral blood of patients with primary immune thrombocytopenia [J]. Journal of Central South Medical Sciences 2019 047(003):294-298. 2. Su Yang, Ren Wenchen, Li Shanshan, et al. Effect of yangjinhua on intestinal Th17/Treg axis in mice with psoriasis based on intestinal-immune-skin axis [J]. Modern Chinese medicine research and practice, 2018, 32(05):31-34. |
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Product Name: (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-22-((2S,2'R,5S,5'S)-5'-((R)-1-hydroxyethyl)-2,5'-dimethyloctahydro-[2,2'-bifuran]-5-yl)-4,6,8,12,14,18,20-heptamethyl-9-oxodocosa-10,16-dienoicacid Request for quotationCAS: 56092-81-0
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