离子霉素
离子霉素(Ionomycin (free acid))
CAS: 56092-81-0
化学式: C41H72O9
| 中文名 | 离子霉素 |
| 英文名 | Ionomycin (free acid) |
| 别名 | 碘霉素 离子霉素 离子霉素(乙醇溶液) 离子霉素, 来源于链霉菌 IONOMYCIN游离态 罗红霉素(游离酸)(链霉菌属载体) 来自共生链霉菌的IONOMYCIN |
| 英文别名 | SQ-23377 IONOMYCIN Ionomycin SQ 23377, EM 94 Ionomycin (free acid) Ionomycin,Free Acid,from Streptomyces conglbatus Ionomycin, free acid, from Streptomyces conglobatus Ionomycin,Free Acid,from Streptomyces conglbatus ionomycin calcium salt from streptomyces conglobatus (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-10,16-docosadienoicacid (4R,6S,8S,10Z,12R,14R,16E,18S,19S,20R,21S)-11,19,21-Trihydroxy-22-{(2S,2'S,5S,5'R)-5'-[(1S)-1-hydroxyethyl]-2,5'-dimethyloctahydro-2,2'-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-9-oxo-10,16-docosadi enoic acid (4R,6S,8R,12R,14S,18S,19R,20R,21R)-19,21-Dihydroxy-22-[(2R,5R)-5-[(2R,5S)-5-(1-hydroxyethyl)-5-methyl-oxolan-2-yl]-5-methyl-oxolan-2-yl]-4,6,8,12,14,18,20-heptamethyl-11-oxido-9-oxo-docosa-10,16-dienoate calcium salt |
| CAS | 56092-81-0 |
| 化学式 | C41H72O9 |
| 分子量 | 709.01 |
| 密度 | 1.072±0.06 g/cm3(Predicted) |
| 熔点 | 204℃-206℃ |
| 沸点 | 817.2±65.0 °C(Predicted) |
| 溶解度 | 溶于乙醇至10 mm，溶于DMSO至10 mm。 |
| 酸度系数 | 4.77±0.10(Predicted) |
| 存储条件 | −20°C |
| 稳定性 | 从提供的购买之日起稳定1年。在DMSO或乙醇中的溶液可以在-20 ° 储存长达3个月。 |
| 敏感性 | Sensitive to light |
| 外观 | 蜡状固体 |
| 颜色 | Yellow |
| BRN | 3642126 |
| 物化性质 | 生物活性 Ionomycin (SQ23377) 是一种有效的，选择性的钙离子载体 (calcium ionophore)，也是一种由 Streptomyces conglobatus 产生的抗生素。Ionomycin (SQ23377) 对二价阳离子具有高度特异性 (Ca>Mg>Sr=Ba)。Ionomycin (SQ23377) 促进细胞凋亡。Ionomycin (SQ23377) 还诱导蛋白激酶C (PKC) 激活。 |
| MDL号 | MFCD06798385 |
| 体外研究 | Ionomycin is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus . Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca 2+ concentration from 50 to 180 nM. DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Necrosis could be detected in ~1-5% of the Ionomycin treated cells. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment. Ionomycin-mediated cleavage and exosome release. Following Ionomycin exposure, medium conditioned by SKOV3ip cells had increased amounts of exosomes containing the L1-32 cleavage fragment. |
| 危险品标志 | Xn - 有害物品 Xi - 刺激性物品  |
| 风险术语 | R22 - 吞食有害。 R36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
| 安全术语 | S36 - 穿戴适当的防护服。 S36/37/39 - 穿戴适当的防护服、手套和护目镜或面具。 S27 - 一旦衣物受到污染，请立即脱去。 S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 S24/25 - 避免与皮肤和眼睛接触。 |
| WGK Germany | 3 |
| RTECS | NO0650000 |
| FLUKA BRAND F CODES | 8-10 |
| 海关编号 | 29419090 |
| Hazard Class | 3 |
| 参考资料 展开查看 | 1. 罗源 唐岚 廖春淑. 原发免疫性血小板减少症患者外周血中Th9/Th17的水平及意义[J]. 中南医学科学杂志 2019 047(003):294-298. 2. 苏阳, 任文晨, 李珊珊,等. 基于肠-免疫-皮肤轴探讨洋金花对银屑病小鼠肠道Th17/Treg轴的影响[J]. 现代中药研究与实践, 2018, 32(05):31-34. |
供应商列表
现货供应
产品名: (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-三羟基-22-((2S,2'R,5S,5'S)-5'-((R)-1-羟乙基)-2,5'-二甲基八氢-[2,2'-联呋喃]-5-基)-4,6,8,12,14,18,20-七甲基-9-氧代二十二烷-10,16-二烯酸 询盘CAS: 56092-81-0
产地: 上海
包装: 10mg；1mg；5mg
规格: 98%10mg/mL
价格: 电话、微信、QQ、邮件
库存: 现货
电话: 400-968-2212
手机: 18916960931
电子邮件: 3623107365@qq.com
QQ: 3623107365
微信: 18916960931
产品描述: (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-三羟基-22-((2S,2'R,5S,5'S)-5'-( 更多
现货供应
产品名: (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-三羟基-22-((2S,2'R,5S,5'S)-5'-((R)-1-羟乙基)-2,5'-二甲基八氢-[2,2'-联呋喃]-5-基)-4,6,8,12,14,18,20-七甲基-9-氧代二十二烷-10,16-二烯酸 询盘CAS: 56092-81-0
产地: 上海
包装: 10mg；1mg；5mg
规格: 98%10mg/mL
价格: 电话、微信、QQ、邮件
库存: 现货
电话: 400-968-2212
手机: 18916960931
电子邮件: 3623107365@qq.com
QQ: 3623107365
微信: 18916960931
产品描述: (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-三羟基-22-((2S,2'R,5S,5'S)-5'-( 更多
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