D-4476
D4476
CAS: 301836-43-1
Molecular Formula: C23H18N4O3
D-4476 - Names and Identifiers
D-4476 - Physico-chemical Properties
| Molecular Formula | C23H18N4O3 |
| Molar Mass | 398.41 |
| Density | 1.338±0.06 g/cm3(Predicted) |
| Boling Point | 675.0±55.0 °C(Predicted) |
| Solubility | DMSO: ~20mg/mL |
| Appearance | Solid |
| Color | light yellow |
| pKa | 10.16±0.10(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | D4476 is a potent and rather selective inhibitor of CK1 in vitro and in cells. In H4IIE hepatoma cells, D4476 specifically inhibits the phosphorylation of endogenous forkhead box transcription factor O1a (FOXO1a) on Ser322 and Ser325 within its MPD, without affecting the phosphorylation of other sites. CK1δ assayed at 0.1 mM ATP using a phosphorylated peptide TFRPRTSpSNASTIS corresponding to residues 312–325 of FOXO1a is inhibited with an IC 50 value of 0.3 μM. The IC 50 value for CK1δ decreases progressively as the concentration of ATP is lowered, indicating that D4476 is an ATP-competitive inhibitor of CK1. CK1. |
D-4476 - Risk and Safety
| WGK Germany | 3 |
D-4476 - Reference Information
| biological activity | D4476 is a CK1 inhibitor with effectiveness, selectivity and cell permeability. Its IC50 value in vitro experiments is 0.3 μM. |
| target | CK1 0.3 μM (IC 50 ) |
| in vitro study | d4476 is a potent and rather selective inhibitor of CK1 in vitro and in cells. in h4iie hepatoma cells, d4476 specifically inhibits the phosphorylation of endogenous forkhead box transcription factor O1a (FOXO1a) on ser322 and ser325 within its MPD, without affecting the phosphorylation of other sites. CK1δ assayed at 0.1 mM ATP using a phosphorylated peptide TFRPRTSpSNASTIS corresponding to residues 312-325 of FOXO1a is inhibited with an IC 50 value of 0.3 μ m. the IC 50 value for CK1δ decreases progressively as the concentration of ATP is lowered, indicating that D4476 is an ATP-competitive inhibitor of CK1. |
Last Update：2024-04-09 02:00:00
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Tel: +86-18821248368
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Product Name: D4476 Request for quotationCAS: 301836-43-1
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Product Name: D4476 Visit Supplier Webpage Request for quotationCAS: 301836-43-1
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Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Casein Kinase I Inhibitor Visit Supplier Webpage Request for quotationCAS: 301836-43-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
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View History
D-4476
976-56-7
KM11060
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还原橄榄绿R
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NA 1557
354545-63-4
175204-80-5
976-56-7
KM11060
Disodium oxalate
(2-Propenyloxy)propanol
还原橄榄绿R
DPP Coral Red
NA 1557
354545-63-4
175204-80-5