Crotamiton
Crotamiton
CAS: 483-63-6
Molecular Formula: C13H17NO
Crotamiton - Names and Identifiers
| Name | Crotamiton |
| Synonyms | Eurax Eurasil Crotalgin Crotamiton Crotamitex Crotamitone component of Eurax N-ethylcroton-o-toluidide N-Ethyl-O-Crotonotoluidine N-ethyl-N-(2-methylphenyl)but-2-enamide 2-Butenamide, N-ethyl-N-(2-methylphenyl)- (2E)-N-Ethyl-N-(2-methylphenyl)-2-butenamide (2E)-N-ethyl-N-(2-methylphenyl)but-2-enamide N-Ethyl-o-crotonotoluidide,predominantly trans 2-(acetyloxy)-N,N,N-trimethylethanaminium chloride |
| CAS | 483-63-6 |
| EINECS | 207-596-3 |
| InChI | InChI=1/C13H17NO/c1-4-8-13(15)14(5-2)12-10-7-6-9-11(12)3/h4,6-10H,5H2,1-3H3/b8-4+ |
| InChIKey | DNTGGZPQPQTDQF-XBXARRHUSA-N |
Crotamiton - Physico-chemical Properties
| Molecular Formula | C13H17NO |
| Molar Mass | 203.28 |
| Density | 0.987 g/mL at 25 °C (lit.) |
| Melting Point | 25°C |
| Boling Point | 153-155 °C/13 mmHg (lit.) |
| Flash Point | >230°F |
| Water Solubility | Soluble in water (1:500), alcohol, methanol, ether, and ethanol. |
| Solubility | ethanol: soluble |
| Vapor Presure | 0.00331mmHg at 25°C |
| Appearance | neat |
| Color | Colourless to Light Brown |
| Merck | 13,2622 |
| pKa | 1.14±0.50(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Light Sensitive |
| Refractive Index | n20/D 1.54(lit.) |
| Use | Anti-scabies, used in the treatment of scabies, skin itching |
Crotamiton - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/38 - Irritating to eyes and skin. R43 - May cause sensitization by skin contact |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | GQ7000000 |
| HS Code | 2924296000 |
Crotamiton - Trait
Authoritative Data Verified Data
- This product is colorless to light yellow oily liquid; Slightly odor; Can be partially or completely cured at low temperature.
- This product is easily soluble in ethanol or ether and slightly soluble in water.
relative density
The relative density of this product (General 0601) is 1.008~1.011.
refractive index
The refractive index of this product (General 0622) is 1.540~1.542.
Last Update：2022-01-01 11:55:49
Crotamiton - Standard
Authoritative Data Verified Data
This product is a mixture of cis and trans isomers of N-ethyl-N-(2-methylphenyl)-2-butenamide. The C13H17NO content should range from 98.0% to 102.0%.
Last Update：2024-01-02 23:10:35
Crotamiton - Differential diagnosis
Authoritative Data Verified Data
- take about 10ml of the saturated aqueous solution of this product, add a few drops of potassium permanganate test solution, that is, Brown, and form a brown precipitate after standing.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- take this product and add cyclohexane to make a solution containing about 10ug per 1 ml. According to ultraviolet-visible spectrophotometry (General 0401), there is a maximum absorption at the wavelength of 242nm.
Last Update：2022-01-01 11:55:49
Crotamiton - Exam
Authoritative Data Verified Data
cis-isomer
if there is a cis isomer peak in the chromatogram of the test solution under the content determination item, the peak area shall not exceed 15% of the sum of the cis and trans isomer peak areas.
Related substances
take an appropriate amount of this product, accurately weigh, add mobile phase to dissolve and dilute to make a solution containing about 0.5mg per lml, as a test solution; Take a sample solution of lml with precision, set in a 100ml measuring flask, dilute to the scale with the mobile phase, and shake to serve as a control solution. According to the chromatographic conditions under the content determination item, 20 u1 of the test solution and the control solution are accurately measured and injected into the human liquid chromatograph respectively, the chromatogram was recorded to 2.5 times the retention time of the trans-isomer peak of clomiphene. N-ethyl-N -(2-tolyl)-3-butenamide (impurity I) with relative retention time of 0.7-0.8, if any, in the chromatogram of the test solution the peak area shall not be greater than 0.75 times (0.75%) of the sum of the peak areas of cis and trans isomers in the control solution; Except for cis isomers and impurity I, the sum of the peak areas of other impurities shall not be greater than cis and trans isomers in the control solution, sum of trans-isomer peak areas (1.0%). The chromatogram of the test solution is 0.02 times smaller than the sum of the peak areas of cis-and trans-isomers in the control solution.
chloride
take 1.0g of this product, add 25ml of ethanol and 5ml of 20% sodium hydroxide solution, heat and reflux for 1 hour, let it cool, move to the separating funnel, add 25ml of ether and 10ml of water, shake, let stand to make the layers, separate the water layer, put it in a 50ml Nessler's colorimetric tube, add water to make it 25ml, add 5ml of nitric acid and an appropriate amount of water to make it 50ml, add 1.0 of silver nitrate test solution, and shake it well, check according to law (General rule 0801); Compare with the standard sodium chloride solution 10. OML, 20% sodium hydroxide solution 5ml and the appropriate amount of water to make 25ml, and compare with the control solution made by the same method from "adding nitric acid 5ml, no more concentrated (0.01%).
free amine
Take 5.0g of this product, add 70ml of ether to dissolve, shake extract with dilute hydrochloric acid for 2 times, 10ml each time, combine the extract, wash with ether for 2 times, 50ml each time, the acidic extract was separated, evaporated to dryness on a water bath, and dried to constant weight at 105 ° C., and the remaining residue should not exceed 2.5mg.
ignition residue
not more than 0.1% (General rule 0841).
Last Update：2022-01-01 11:55:50
Crotamiton - Content determination
Authoritative Data Verified Data
measured by high performance liquid chromatography (General 0512).
chromatographic conditions and system suitability test
The mobile phase was cyclohexane-tetrahydrofuran (92:8) and the detection wavelength was 242nm. The relative retention time of clomiprone cis-isomer peak is between 0.5 and 0.6, and the number of theoretical plates is not less than 5000 based on the calculation of clomiprone trans-isomer peak, the degree of separation of the trans-isomer peak of clomiphene from the CIS-isomer peak of clomiphene should be greater than 8.0.
assay
take about 50mg of this product, weigh it accurately, put it in a 100ml measuring flask, add the mobile phase to dissolve and dilute to the scale, shake well, take 5ml accurately and put it in a 100ml measuring flask, dilute to the scale with mobile phase, shake well, as a test solution, take 20ul with precision, inject human liquid chromatograph, record chromatogram; Take another clomiprone reference, precision weigh, same method determination. According to the external standard method, the sum of the peak areas of clomiphene and trans isomer is calculated.
Last Update：2022-01-01 11:55:51
Crotamiton - Category
Authoritative Data Verified Data
Anti-scabies drug.
Last Update：2022-01-01 11:55:51
Crotamiton - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 11:55:51
Crotamiton - Clomiprone cream
Authoritative Data Verified Data
This product contains clomiprone (C13H17NO) should be the label amount of 93.0% ~ 107.0%.
trait
This product is white.
identification
- take 0.2g of this product, heat 10ml of water, fully shake to dissolve clomiphene, filter, add several drops of potassium permanganate to the filtrate, that is, Brown, after static, brown precipitate is formed.
- take an appropriate amount of this product (about 50mg equivalent to clomiprone), add 50ml of cyclohexane, shake to disperse (heat on water bath if necessary), as a test solution; another clomiprone control was taken and a solution containing 1 mg per 1 ml of cyclohexane was prepared as a control solution. According to the thin layer chromatography (General 0502) test, absorb 10ul of each of the above two solutions, respectively point on the same silica gel GF 254 thin layer plate, with methanol as the developing solvent, expand, dry, display under UV light (254mn). The position of the main spot displayed by the test solution should be the same as that of the control solution.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- two items (2) and (3) above can be selected as one item.
examination
should comply with the relevant provisions under Cream (General rule 0109).
Content determination
take an appropriate amount of this product (about 25TNG equivalent to clomiprone), weigh it accurately, put it in a 50ml measuring flask, add an appropriate amount of cyclohexane, put it in a hot water bath, shake it to dissolve clomiprone, cool to room temperature. Add cyclohexane to dilute to the scale, shake well, stand still for 1 hour, and add 5ml solution to the top, put it in a 100ml measuring flask, dilute with cyclohexane to the scale, shake well, as the test solution, the measurement was carried out according to the method under the item of measuring the content of clomiphene. Another reference substance of clomiprone was precision weighed, dissolved and quantitatively diluted with cyclohexane to make a solution containing about 25ug per lml, which was determined by the same method, the sum of the peak areas of the trans-isomer was calculated.
category
similar to clomiprone.
specification
(l)10g:lg (2)30g:3g
storage
sealed and stored in a cool place.
Last Update：2022-01-01 11:55:52
Crotamiton - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| pharmacological action | clomiprone has local anesthetic effect and can treat various types of pruritus. And has a specific role in killing scabies, can act on the nervous system of scabies, so that the death of scabies paralysis. In addition, the growth of Streptococcus and Staphylococcus was also inhibited. |
| indications | clomib is commonly used in the treatment of scabies, pruritus and secondary skin infections. |
| biological activity | Crotamiton is used as an antipruritic agent for scabies. |
| Use | Anti-scabies drug for the treatment of scabies and itchy skin. used in various allergic skin diseases and cosmetic additives Anti-scabies mite drug for the treatment of scabies, skin itching, etc |
Last Update：2024-04-09 19:05:07
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View History
Crotamiton
98-42-0
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98-42-0
trimetazidine
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4,4'-oxybisbenzenamine
2456-81-7
C.I. Direct Yellow 11,lithium salt
1263103-46-3