1201-07-6
8-Bromo-4-chloro-2-methylquinoline
CAS: 1201-07-6
Molecular Formula: C10H7BrClN
1201-07-6 - Names and Identifiers
| Name | 8-Bromo-4-chloro-2-methylquinoline |
| Synonyms | 8-BROMO-4-CHLOROQUINALDINE 8-Bromo-4-chloro-2-methylquinoline 2-Methyl-4-chloro-8-BroMoquinoline 8-BROMO-4-CHLORO-2-METHYLQUINOLINE |
| CAS | 1201-07-6 |
| InChI | InChI=1/C10H7BrClN/c1-6-5-9(12)7-3-2-4-8(11)10(7)13-6/h2-5H,1H3 |
1201-07-6 - Physico-chemical Properties
| Molecular Formula | C10H7BrClN |
| Molar Mass | 256.53 |
| Density | 1.591g/cm3 |
| Boling Point | 321.9°C at 760 mmHg |
| Flash Point | 148.5°C |
| Vapor Presure | 0.000546mmHg at 25°C |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.661 |
1201-07-6 - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R25 - Toxic if swallowed R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
1201-07-6 - Introduction
8-bromo -4-chloro -2-methyl quinoline is an organic compound, its molecular formula is C10H8BrClN, structural formula is BrClC6H4CH2N. The following is an introduction to its nature, use, preparation and safety information:
Nature:
1. Appearance: 8-bromo -4-chloro -2-methyl quinoline is a white or slightly yellow solid.
2. Melting point: Its melting point is 97-98°C.
3. Solubility: 8-bromo -4-chlorine -2-methyl quinoline can be dissolved in some organic solvents, such as chloroform, ethyl acetate and dichloromethane.
Use:
1. Chemical reagent: 8-bromo -4-chloro -2-methyl quinoline is commonly used as a reagent in organic synthesis, especially as an important starting material in drug synthesis.
2. pharmaceutical field: it is used in the field of medicine to synthesize certain drugs, such as antibacterial drugs and anti-tumor drugs.
Preparation Method:
8-Bromo-4-chloro-2-methylquinoline can be synthesized by the following steps:
1. First, 2-methyl quinoline is reacted with sodium nitrite to generate 2-nitro -4-methyl quinoline under acidic conditions.
2. Then, 2-nitro-4-methylquinoline is reacted with brominated sulfoxide to generate 8-bromo-4-methylquinoline.
3. Finally, 8-bromo-4-methylquinoline is reacted with thionyl chloride to obtain 8-bromo-4-chloro-2-methylquinoline.
Safety Information:
1. 8-Bromo-4-chloro-2-methylquinoline is an organic compound that may be toxic to some extent, so care should be taken in the correct manner when using it and avoid contact with skin, eyes or inhalation of its vapors.
2. When used under laboratory conditions, wear appropriate personal protective equipment, such as laboratory gloves, protective glasses and laboratory coats.
3. 8-Bromo-4-chloro-2-methylquinoline must be stored in a sealed container, away from fire and oxidizing agents.
4. in the treatment of the compound, should follow the correct method of waste disposal, to prevent pollution of the environment.
Nature:
1. Appearance: 8-bromo -4-chloro -2-methyl quinoline is a white or slightly yellow solid.
2. Melting point: Its melting point is 97-98°C.
3. Solubility: 8-bromo -4-chlorine -2-methyl quinoline can be dissolved in some organic solvents, such as chloroform, ethyl acetate and dichloromethane.
Use:
1. Chemical reagent: 8-bromo -4-chloro -2-methyl quinoline is commonly used as a reagent in organic synthesis, especially as an important starting material in drug synthesis.
2. pharmaceutical field: it is used in the field of medicine to synthesize certain drugs, such as antibacterial drugs and anti-tumor drugs.
Preparation Method:
8-Bromo-4-chloro-2-methylquinoline can be synthesized by the following steps:
1. First, 2-methyl quinoline is reacted with sodium nitrite to generate 2-nitro -4-methyl quinoline under acidic conditions.
2. Then, 2-nitro-4-methylquinoline is reacted with brominated sulfoxide to generate 8-bromo-4-methylquinoline.
3. Finally, 8-bromo-4-methylquinoline is reacted with thionyl chloride to obtain 8-bromo-4-chloro-2-methylquinoline.
Safety Information:
1. 8-Bromo-4-chloro-2-methylquinoline is an organic compound that may be toxic to some extent, so care should be taken in the correct manner when using it and avoid contact with skin, eyes or inhalation of its vapors.
2. When used under laboratory conditions, wear appropriate personal protective equipment, such as laboratory gloves, protective glasses and laboratory coats.
3. 8-Bromo-4-chloro-2-methylquinoline must be stored in a sealed container, away from fire and oxidizing agents.
4. in the treatment of the compound, should follow the correct method of waste disposal, to prevent pollution of the environment.
Last Update：2024-04-09 21:01:54
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