CS-2786
WAY 316606
CAS: 915759-45-4
Molecular Formula: C18H19F3N2O4S2
CS-2786 - Names and Identifiers
CS-2786 - Physico-chemical Properties
| Molecular Formula | C18H19F3N2O4S2 |
| Molar Mass | 448.4796696 |
| Density | 1.50±0.1 g/cm3(Predicted) |
| Boling Point | 601.1±65.0 °C(Predicted) |
| pKa | 8.76±0.20(Predicted) |
| Storage Condition | 2-8℃ |
| In vitro study | The EC 50 of WAY-316606 for Wnt-Luciferase Activity from U2-OS Cells is 0.65 μM. WAY-316606 binds to secreted frizzled-related protein (sFRP)-1 inhibitor with a K D of 0.08 μM and inhibits sFRP-1 with an EC 50 of 0.65 μM. WAY-316606 also binds to sFRP-2, albeit over 10 times weaker with a K D of 1 μM. Using a fluorescence polarization binding assay that employs a fluorescent probe compound and purified human sFRP-1 protein in a competitive-binding format, the IC 50 for WAY-316606 is 0.5 μM. |
| In vivo study | WAY-316606 increases bone formation when tested in a neonatal murine calvarial assay. WAY-316606 increases total bone area up to 60% in a dose-dependent manner with an EC 50 of about 1 nM. WAY-316606 has good aqueous solubility, moderate to low inhibition of cytochrome p450 isozymes (3A4, 2D6, 2C9) and good stability in rat and human liver microsomes (t 1/2 >60 min in each species). In female Sprague-Dawley rats, WAY-316606 exhibits high plasma clearance (77 mL/min/kg, greater than hepatic blood flow) following a single intravenous bolus dose (2 mg/kg), which results in a rapid decline of drug exposure in the plasma despite the route of administration. |
CS-2786 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.23 ml | 11.149 ml | 22.298 ml |
| 5 mM | 0.446 ml | 2.23 ml | 4.46 ml |
| 10 mM | 0.223 ml | 1.115 ml | 2.23 ml |
| 5 mM | 0.045 ml | 0.223 ml | 0.446 ml |
Last Update：2024-01-02 23:10:35
Supplier List
Spot supply
Product Name: WAY-316606 Request for quotationCAS: 915759-45-4
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: WAY-316606 Visit Supplier Webpage Request for quotationCAS: 915759-45-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple Specifications
Product Name: WAY 316606 Request for quotationCAS: 915759-45-4
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: +8613651600618
WhatsApp: +8613651600618
Spot supply
Product Name: WAY 316606 Visit Supplier Webpage Request for quotationCAS: 915759-45-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: WAY 316606 Visit Supplier Webpage Request for quotationCAS: 915759-45-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)- Visit Supplier Webpage Request for quotation
CAS: 915759-45-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 915759-45-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: WAY-316606 Request for quotationCAS: 915759-45-4
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: WAY-316606 Visit Supplier Webpage Request for quotationCAS: 915759-45-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple Specifications
Product Name: WAY 316606 Request for quotationCAS: 915759-45-4
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: +8613651600618
WhatsApp: +8613651600618
Spot supply
Product Name: WAY 316606 Visit Supplier Webpage Request for quotationCAS: 915759-45-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: WAY 316606 Visit Supplier Webpage Request for quotationCAS: 915759-45-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)- Visit Supplier Webpage Request for quotation
CAS: 915759-45-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 915759-45-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
CS-2786
GRATIL
Cbz-R-3-Amino-γ-butyrolactone
SODIUM HEXANOATE
117635-21-9
sulfadimidine
844648-22-2
ceraphyl368
GRATIL
Cbz-R-3-Amino-γ-butyrolactone
SODIUM HEXANOATE
117635-21-9
sulfadimidine
844648-22-2
ceraphyl368