BRD-7552
BRD7552
CAS: 1137359-47-7
Molecular Formula: C33H33N3O15
BRD-7552 - Names and Identifiers
BRD-7552 - Physico-chemical Properties
| Molecular Formula | C33H33N3O15 |
| Molar Mass | 711.63 |
| Density | 1.53±0.1 g/cm3(Predicted) |
| Boling Point | 757.6±60.0 °C(Predicted) |
| Solubility | DMSO: ≥ 38 mg/mL |
| pKa | 11.81±0.20(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | BRD7552 (0-5 μM; 5 days) induces a dose-dependent increase in PDX1 protein levels after BRD7552 treatment in PANC-1 cells. BRD7552 acts in a FOXA2-dependent manner to increase PDX1 expression in human ductal cells. Nine-day treatment of PANC-1 cells with BRD7552 (0-10 μM) causes a dose-dependent increase in insulin mRNA expression. BRD7552 induces insulin expression in PANC-1 cells. BRD7552 increases H3 acetylation and H3K4me3 and decreases H3K9me3, results that are consistent with transcriptional activation of PDX1. The epigenetic changes induced by BRD7552 are consistent with transcriptional activation, and BRD7552 acts in a FOXA2-dependent manner. Western Blot Analysis Cell Line: PANC-1 cells Concentration: 1.25, 2.5, 5 μM Incubation Time: 5 days Result: Induced a dose-dependent increase in PDX1 protein levels. |
BRD-7552 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.405 ml | 7.026 ml | 14.052 ml |
| 5 mM | 0.281 ml | 1.405 ml | 2.81 ml |
| 10 mM | 0.141 ml | 0.703 ml | 1.405 ml |
| 5 mM | 0.028 ml | 0.141 ml | 0.281 ml |
Last Update：2024-01-02 23:10:35
BRD-7552 - Reference Information
| Biological activity | BRD7552 is a PDX1 transcription factor inducer, which upregulates the expression of PDX1 in primary human islets and ductal cells, and induces The epigenetic changes of the PDX1 promoter are consistent with transcriptional activation. BRD7552 increases insulin expression. PDX1 is a key transcription factor involved in pancreatic development and β-cell function. |
| in vitro study | BRD7552 (0-5μM; 5 days) induces a dose-dependent increase in PDX1 protein levels after BRD7552 treatment in PANC-1 cells. BRD7552 acts in a FOXA2-dependent banner to increase PDX1 expression in human ductal cells. Nine-day treatment of PANC-1 cells with BRD7552 (0-10μM) cause a dose-dependent increase in insulin mRNA expression. BRD7552 induces insulin expression in PANC-1 cells. BRD7552 increases H3 acetylation and H3K4me3 and decreases H3K9me3, results that are consistent with transcriptional activation of PDX1. The epigenetic changes induced by BRD7552 are consistent with transcriptional activation, and BRD7552 acts in a FOXA2-dependent manner. Western Blot Analysis Cell Line: PANC-1 cells Concentration: 1.25, 2.5, 5 μ m Incubation Time: 5 days Result: Induced a pose-dependent increase in PDX1 protein levels. |
| Cell Line: | PANC-1 cells |
| Concentration: | 1.25, 2.5, 5 μM |
| Incubation Time: | 5 days |
| Result: | Induced a dose-dependent increase in PDX1 protein levels. |
Last Update：2024-04-09 21:54:55
Supplier List
Featured ProductsSpot supply
Product Name: BRD-7552 Visit Supplier Webpage Request for quotationCAS: 1137359-47-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: BRD7552 Request for quotationCAS: 1137359-47-7
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: BRD7552 Visit Supplier Webpage Request for quotationCAS: 1137359-47-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: BRD7552 Visit Supplier Webpage Request for quotationCAS: 1137359-47-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: BRD7552 Visit Supplier Webpage Request for quotation
CAS: 1137359-47-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1137359-47-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: BRD-7552 Visit Supplier Webpage Request for quotationCAS: 1137359-47-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: BRD7552 Request for quotationCAS: 1137359-47-7
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: BRD7552 Visit Supplier Webpage Request for quotationCAS: 1137359-47-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: BRD7552 Visit Supplier Webpage Request for quotationCAS: 1137359-47-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: BRD7552 Visit Supplier Webpage Request for quotation
CAS: 1137359-47-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1137359-47-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History