BML-GR362
Tubacin
CAS: 537049-40-4
Molecular Formula: C41H43N3O7S
BML-GR362 - Names and Identifiers
BML-GR362 - Physico-chemical Properties
| Molecular Formula | C41H43N3O7S |
| Molar Mass | 721.86 |
| Melting Point | 155 - 157°C |
| Solubility | DMSO: ≥10mg/mL |
| Appearance | powder |
| Color | white to tan |
| Storage Condition | -20°C |
| In vitro study | In A549 cells, Tubacin increased α-tubulin acetylation without directly stabilizing microtubules, with an EC50 of 2.5 μm. Tubacin inhibits hdac6-mediated α-tubulin deacetylation and inhibits the migration of wild-type and HDAC6 overexpressing cells. The combined use of paclitaxel and Tubacin significantly increased tubulin acetylation. Tubacin significantly inhibits the growth of drug-sensitive and drug-resistant MM cells with an IC50 of 5-20 μm and induces apoptosis by activating caspases. |
| In vivo study | In chicken embryos, Tubacin inhibits HDAC6 activity and reduces the formation of new blood vessels in the artificial basement membrane/polyamide fiber mesh. Tubacin also damaged neovascularization in a mouse model of angioreactors transplantation. |
BML-GR362 - Risk and Safety
| WGK Germany | 3 |
BML-GR362 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.385 ml | 6.927 ml | 13.853 ml |
| 5 mM | 0.277 ml | 1.385 ml | 2.771 ml |
| 10 mM | 0.139 ml | 0.693 ml | 1.385 ml |
| 5 mM | 0.028 ml | 0.139 ml | 0.277 ml |
Last Update：2024-01-02 23:10:35
BML-GR362 - Introduction
Tubacin is a compound with the chemical name N-[[4-(1,4-benzodioxan-2-yl)methyl]phenyl]benzamide. It is a selective histone deacetylase inhibitor that inhibits intracellular HDAC6 (histone deacetylase 6). Tubacin are mainly used in biomedical research, especially in cancer treatment and neurodegenerative diseases.
The preparation method of Tubacin is more complicated, mainly including the synthesis of intermediates of deacetylase inhibitor and aniline, and then nucleophilic substitution reaction to synthesize Tubacin. The preparation process generally needs to be carried out under the conditions of organic synthesis in the chemical laboratory.
The preparation method of Tubacin is more complicated, mainly including the synthesis of intermediates of deacetylase inhibitor and aniline, and then nucleophilic substitution reaction to synthesize Tubacin. The preparation process generally needs to be carried out under the conditions of organic synthesis in the chemical laboratory.
Last Update：2024-04-09 01:59:51
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Mobile: 609-228-6898
Product Name: Tubacin Visit Supplier Webpage Request for quotation
CAS: 537049-40-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 537049-40-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: Tubacin Visit Supplier Webpage Request for quotationCAS: 537049-40-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Tubacin Request for quotationCAS: 537049-40-4
Tel: 0712-8899838
Email: jy6101@rmastandards.com
Mobile: 86-15787876101
QQ: 2518299249
Wechat: 15787876101
Spot supply
Product Name: Tubacin Request for quotationCAS: 537049-40-4
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Tubacin Visit Supplier Webpage Request for quotationCAS: 537049-40-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: Tubacin Visit Supplier Webpage Request for quotationCAS: 537049-40-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: Tubacin Visit Supplier Webpage Request for quotation
CAS: 537049-40-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 537049-40-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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