Molecular Formula | C41H43N3O7S |
Molar Mass | 721.86 |
Melting Point | 155 - 157°C |
Solubility | DMSO: ≥10mg/mL |
Appearance | powder |
Color | white to tan |
Storage Condition | -20°C |
In vitro study | In A549 cells, Tubacin increased α-tubulin acetylation without directly stabilizing microtubules, with an EC50 of 2.5 μm. Tubacin inhibits hdac6-mediated α-tubulin deacetylation and inhibits the migration of wild-type and HDAC6 overexpressing cells. The combined use of paclitaxel and Tubacin significantly increased tubulin acetylation. Tubacin significantly inhibits the growth of drug-sensitive and drug-resistant MM cells with an IC50 of 5-20 μm and induces apoptosis by activating caspases. |
In vivo study | In chicken embryos, Tubacin inhibits HDAC6 activity and reduces the formation of new blood vessels in the artificial basement membrane/polyamide fiber mesh. Tubacin also damaged neovascularization in a mouse model of angioreactors transplantation. |
WGK Germany | 3 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 1.385 ml | 6.927 ml | 13.853 ml |
5 mM | 0.277 ml | 1.385 ml | 2.771 ml |
10 mM | 0.139 ml | 0.693 ml | 1.385 ml |
5 mM | 0.028 ml | 0.139 ml | 0.277 ml |