| Molecular Formula | C21H20N4O2 |
| Molar Mass | 360.41 |
| Solubility | 10 mM in DMSO |
| Appearance | powder |
| Color | light yellow to dark yellow |
| Storage Condition | 2-8°C |
| In vitro study | BMH-21 causes proteasome-dependent destruction of RPA194, the large catalytic subunit protein of Pol I holocomplex. In U2OS cancer cell line, BMH-21 results in degradation of RPA194 and translocation of NCL with IC50 of 0.05 μM and 0.07 μM, respectively. By causing nucleolar stress, BMH-21 also shows potent inhibition on cell viability. |
| In vivo study | BMH-21 reduces tumor growth in mouse xenografts. |
| Hazard Symbols | Xn - Harmful![]() |
| Risk Codes | 22 - Harmful if swallowed |
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.775 ml | 13.873 ml | 27.746 ml |
| 5 mM | 0.555 ml | 2.775 ml | 5.549 ml |
| 10 mM | 0.277 ml | 1.387 ml | 2.775 ml |
| 5 mM | 0.055 ml | 0.277 ml | 0.555 ml |