908303-26-4

908303-26-4 - Names and Identifiers

Name	(2R)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilyl)oxy]methyl}pyrrolidine
Synonyms	(R)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]prolinol trimethylsilyl ether R-2-[bis[3,5-bis(trifluoroMethyl)phenyl][(triMethylsilyl)oxy]Methyl]-Pyrrolidine (2R)-2-[Bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilyl)oxy]methyl]pyrrolidine (2R)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilyl)oxy]methyl}pyrrolidine (R)-2-[(Bis(3,5-bis(trifluoroMethyl)phenyl)]triMethylsilanyloxy)Methyl]pyrrolidine [bis[3,5-bis(trifluoromethyl)phenyl]-[(2R)-pyrrolidin-2-yl]methoxy]-trimethylsilane Pyrrolidine, 2-[bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilyl)oxy]methyl]-, (2R)- (R)-alpha,alpha-Bis[3,5-bis(trifluoroMethyl)phenyl]-2-pyrrolidineMethanol triMethylsilyl ether technical grade
CAS	908303-26-4
InChI	InChI=1/C24H23F12NOSi/c1-39(2,3)38-20(19-5-4-6-37-19,13-7-15(21(25,26)27)11-16(8-13)22(28,29)30)14-9-17(23(31,32)33)12-18(10-14)24(34,35)36/h7-12,19,37H,4-6H2,1-3H3/t19-/m1/s1

908303-26-4 - Physico-chemical Properties

Molecular Formula	C24H23F12NOSi
Molar Mass	597.51
Density	1.319±0.06 g/cm3(Predicted)
Melting Point	46-55°C
Boling Point	382.4±37.0 °C(Predicted)
Flash Point	>110℃
Solubility	Chloroform (Slightly), Ethyl Acetate (Slightly)
Vapor Presure	4.72E-06mmHg at 25°C
Appearance	Solid
Color	White to Off-White
pKa	9.34±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.439

908303-26-4 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany	3

908303-26-4 - Introduction

(2R)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilyl)oxy]methyl}pyrrolidine is an organic compound whose molecular formula is C22H23F6NO2Si. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: colorless or light yellow liquid
-Melting point:-20 ℃
-Boiling Point: 130-135 ℃(0.5 mmHg)
-Density: 1.251 g/mL
-Refractive Index: 1.484

Use:
(2R)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilyl)oxy]methyl}pyrrolidine is commonly used as a ligand for chiral catalysts and can be used for asymmetric catalytic reactions, such as asymmetric nucleophilic substitution reactions and Suzuki coupling reactions. It can also be used for other chiral induction reactions in organic synthesis.

Method: The synthesis of
(2R)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilyl)oxy]methyl}pyrrolidine is usually accomplished in a two-step reaction. The first step is the reaction of (2R)-2-ethoxycarbonyl-1-pyrrole boronate with 3,5-ditrifluoromethylphenylboronate to give (2R)-2-ethoxycarbonyl-1-[3,5-bis(trifluoromethyl)phenyl]pyrrolidine. The second step is to react the resulting product with chloromethyltrimethylsilane to give the final product.

Safety Information:
(2R)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilyl)oxy]methyl}pyrrolidine safety information related to less reported, but in general, the use of chemicals should pay attention to protective measures, avoid contact with skin, eyes and inhalation. Personal protective equipment should be worn during use and good ventilation should be maintained. In case of inadvertent contact or ingestion, seek medical attention and bring relevant chemical information.

Last Update：2024-04-10 22:29:15