Molecular Formula | C22H19N5O |
Molar Mass | 369.42 |
Density | 1.40 |
Melting Point | 241-242°C |
Boling Point | 619.0±55.0 °C(Predicted) |
Flash Point | 328.162℃ |
Solubility | DMSO 74 mg/mL (200.31 mM); Water <1 mg/mL (<1 mM);Ethanol <1 mg/mL (<1 mM) |
Appearance | Form solid, color White |
Storage Condition | -20°C |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
Physical and Chemical Properties | Bioactive Galunisertib (LY2157299) is a potent TGF β receptor I (TβRI) inhibitor with an IC50 of 56 nM in cell-free assays. Phase 2/3. |
Use | The LY2157299 of use is TGF-βI receptor kinase inhibitor. LY2157299 has been used to enhance chemotherapy for triple negative breast cancer (TNBC). |
Hazard Symbols | T - Toxic |
Risk Codes | 25 - Toxic if swallowed |
Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
HS Code | 29334900 |
Solubility | Soluble in DMSO (up to 25 mg/ml) |