6-Iodoquinoline
6-Iodoquinoline
CAS: 13327-31-6
Molecular Formula: C9H6IN
6-Iodoquinoline - Names and Identifiers
| Name | 6-Iodoquinoline |
| Synonyms | 6-IodoquinoL 6-Iodchinolin 6-IODOQUINOLINE 6-Iodoquinoline 6-Iodoquinolone 6-iodo-Quinoline Quinoline, 6-iodo- 6-Iodo-1-azanaphthalene |
| CAS | 13327-31-6 |
| EINECS | 663-773-9 |
| InChI | InChI=1/C9H6IN/c10-8-3-4-9-7(6-8)2-1-5-11-9/h1-6H |
| InChIKey | WKTASELJZCIVBR-UHFFFAOYSA-N |
6-Iodoquinoline - Physico-chemical Properties
| Molecular Formula | C9H6IN |
| Molar Mass | 255.06 |
| Density | 1.7856 (estimate) |
| Melting Point | 91°C |
| Boling Point | 120 °C(Press: 1 Torr) |
| Flash Point | 147.8°C |
| Vapor Presure | 0.000585mmHg at 25°C |
| pKa | 4.23±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.724 |
6-Iodoquinoline - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29334900 |
6-Iodoquinoline - Reference Information
| Application | 6-iodoquinoline is an organic intermediate, which can be obtained by 6-bromoquinoline iodide. There are reports that it can be used to prepare triazolopyridazine tyrosine kinase inhibitors. |
| preparation | sodium iodide (4.32g,28.8mmol), copper iodide (I)(137mg,0.72mmol) and N,N '-dimethyl-cyclohexane -1,2-diamine (0.227ml,1.44mmol) and 6-bromoquinoline (3g,14.4mmol) in dioxane (15mL) were loaded into 25mL tubes. The tube is purged with nitrogen and sealed with a polytetrafluoroethylene diaphragm, allowing nitrogen to foam in the solution for 10 minutes, and the gas is allowed to escape with a needle. After the needle was pulled out, the reaction mixture was stirred at 110 ℃ for 15 hours. Then, the green suspension reached room temperature, poured into ice-water, and extracted with dichloromethane. The organic layer is collected, dried (MgSO4), filtered and vacuum concentrated. The crude mixture of CH2Cl 2100% and CH2Cl2/MeOH:95/5 silica gel chromatography was used to obtain 3.56g(97%)6-iodoquinoline in a light yellow solid. |
Last Update：2024-04-09 02:00:03
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