587841-73-4
ZCL278
CAS: 587841-73-4
Molecular Formula: C21H19BrClN5O4S2
587841-73-4 - Names and Identifiers
587841-73-4 - Physico-chemical Properties
| Molecular Formula | C21H19BrClN5O4S2 |
| Molar Mass | 584.89 |
| Appearance | Light beige solid |
| Storage Condition | +2C to +8C |
| In vitro study | ZCL278 inhibits the activity of Cdc42 GTPase by competing with GTP, and shows a time-dependent relationship in the inhibition of Rac/Cdc42 phosphorylation. ZCL278 (50 μm) inhibits Cdc42-mediated microprojection formation, disrupting the GM130-linked Golgi structure in serum-starved Swiss 3T3 fibroblasts. ZCL278 was also able to inhibit Cdc42-mediated neuronal branching, growth cone kinetics and actin-mediated motor migration capacity in metastatic prostate cancer cell line PC-3 without cytotoxicity. |
587841-73-4 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 0 ml | 0 ml | 0 ml |
| 5 mM | 0 ml | 0 ml | 0 ml |
| 10 mM | 0 ml | 0 ml | 0 ml |
| 5 mM | 0 ml | 0 ml | 0 ml |
Last Update：2024-01-02 23:10:35
587841-73-4 - Reference Information
| biological activity | ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM. |
| in vitro study | ZCL278 inhibits the activity of Cdc42 GTPase by competing with GTP, showing a time-sensitive relationship in the inhibition of Rac/Cdc42 phosphorylation. ZCL278 (50 μM) inhibits Cdc42-mediated microprocess formation, disrupting the GM130-linked Golgi structure in serum-starved Swiss 3T3 fibroblasts. ZCL278 can also inhibit Cdc42-mediated neuronal branching, growth cone dynamics and actin-mediated motor migration in metastatic prostate cancer cell line PC-3, and has no cytotoxicity. |
Last Update：2024-04-09 21:54:55
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Product Name: ZCL278 Visit Supplier Webpage Request for quotationCAS: 587841-73-4
Tel: +86-18821248368
Email: Int06@meryer.com
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Product Name: ZCL278 Request for quotationCAS: 587841-73-4
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
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Product Name: ZCL278 Visit Supplier Webpage Request for quotationCAS: 587841-73-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: ZCL278 Visit Supplier Webpage Request for quotationCAS: 587841-73-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: ZCL278 Visit Supplier Webpage Request for quotationCAS: 587841-73-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
587841-73-4
tetraoctylammonium chloride
197715-75-6
156223-05-1
131747-65-4
23789-88-0
1354028-83-3
Adamantane-1,3-DIOL
4-羟基氯苯
1673534-76-3
tetraoctylammonium chloride
197715-75-6
156223-05-1
131747-65-4
23789-88-0
1354028-83-3
Adamantane-1,3-DIOL
4-羟基氯苯
1673534-76-3