312-73-2
2-(Trifluoromethyl)benzimidazole
CAS: 312-73-2
Molecular Formula: C8H5F3N2
312-73-2 - Names and Identifiers
312-73-2 - Physico-chemical Properties
| Molecular Formula | C8H5F3N2 |
| Molar Mass | 186.13 |
| Density | 1.3658 (estimate) |
| Melting Point | 208-211°C(lit.) |
| Boling Point | 262.8±40.0 °C(Predicted) |
| Flash Point | 155.4°C |
| Water Solubility | PRACTICALLY INSOLUBLE |
| Vapor Presure | 0.000137mmHg at 25°C |
| Appearance | Solid |
| pKa | 9.25±0.10(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.54 |
312-73-2 - Risk and Safety
| Risk Codes | R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S28A - |
| UN IDs | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | DE1576000 |
| HS Code | 29332900 |
| Hazard Class | 6.1(a) |
| Packing Group | II |
312-73-2 - Reference Information
| introduction | benzimidazole compounds have anti-HIV-1, anti-tumor, anti-cell proliferation, anti-parasitic, anti-inflammatory, antioxidant and anti-epileptic biological activities. In addition, these compounds are also used as metal ligands. Therefore, the synthesis of such compounds has attracted the attention of chemists. |
| preparation | o-phenylenediamine is dissolved in a 1:1 mixed solution of methanol and water, trifluoroacetic acid is added, and the reaction is under the condition of 50 ℃ 2 hours; After cooling to room temperature, the methanol is removed by decompression concentration, the remaining aqueous phase is added with sodium hydroxide aqueous solution, ethyl acetate is added for extraction twice, and the extracted organic layers are combined, wash the organic phase with purified water and saturated salt water, dry anhydrous magnesium sulfate, filter, spin out the organic solvent under reduced pressure, and recrystallize the residue with ethanol and water to obtain the product 2-(trifluoromethyl) benzimidazole. |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
Last Update：2024-04-09 20:52:54
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