Kartogenin
Kartogenin
CAS: 4727-31-5
Molecular Formula: C20H15NO3
Kartogenin - Names and Identifiers
Kartogenin - Physico-chemical Properties
| Molecular Formula | C20H15NO3 |
| Molar Mass | 317.338 |
| Density | 1.289±0.06 g/cm3(Predicted) |
| Melting Point | 272 °C |
| Boling Point | 464.4±38.0 °C(Predicted) |
| Solubility | DMSO: ≥ 42 mg/mL |
| Appearance | powder |
| Color | White |
| pKa | 3.45±0.36(Predicted) |
| Storage Condition | room temp |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| Physical and Chemical Properties | Bioactive Kartogenin (KGN) is a smad4/smad5 pathway activator, which promotes the selective differentiation of multifunctional mesenchymal stem cells into chondrocytes. |
Kartogenin - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36 - Irritating to the eyes R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
Kartogenin - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.151 ml | 15.756 ml | 31.512 ml |
| 5 mM | 0.63 ml | 3.151 ml | 6.302 ml |
| 10 mM | 0.315 ml | 1.576 ml | 3.151 ml |
| 5 mM | 0.063 ml | 0.315 ml | 0.63 ml |
Last Update：2024-01-02 23:10:35
Kartogenin - Uses and synthesis methods
Target
Target Value
Smad4
Smad5
in vitro studies
Kartogenin induced hMSCs to differentiate into chondrocytes and protected articular chondrocytes by enhancing CBFβ nuclear localization. Kartogenin promotes type I collagen synthesis of dermal fibroblasts by activating the smad4/smad5 pathway without significant cytotoxicity to the activity, morphology and survival of fibroblasts.
In vivo studies
In mouse models of OA caused by collagenase VII (10 μM)-and surgical (100 μM)-Kartogenin promote cartilage repair. Kartogenin (100 nM) also stimulates collagen synthesis in mouse dermis. In addition, Kartogenin stimulated bone growth and synovial joint development in mouse limbs.
Last Update：2024-04-09 21:01:54
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