27113-22-0
6-paradol
CAS: 27113-22-0
Molecular Formula: C17H26O3
27113-22-0 - Names and Identifiers
27113-22-0 - Physico-chemical Properties
| Molecular Formula | C17H26O3 |
| Molar Mass | 278.39 |
| Density | 1.0690 g/cm3 |
| Boling Point | 406.4±30.0 °C(Predicted) |
| JECFA Number | 2021 |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | White to Brown |
| pKa | 10.02±0.20(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.5232 (589.3 nm 20℃ |
| In vitro study | Paradol ([6]-paradol) induces apoptosis in an oral squamous carcinoma cell line, KB, in a dose-dependent manner. Paradol induces apoptosis through a caspase-3-dependent mechanism. |
| In vivo study | Administration of Paradol (6-paradol) (10 mg/kg) clearly reduces the number of Iba1-positive cells 1 and 3 days after the challenge. Moreover, Paradol dramatically reduces the number of Iba1-postive cells in periischemic regions even after 3 days following M/R challenge. Paradol (6-paradol) exhibits the strongest anti-inflammatory effect of several paradol compounds in lipopolysaccharide-stimulated BV2 microglia derived from a mouse brain, including 2-, 4-, 6-, 8-, and 10-paradol. Furthermore, Paradol shows the strongest pungency of all of the known paradol analogues. Paradol also shows the highest contact time at the antiobesity site of action on the basis of the results shown for the absorption of the metabolites in this study. |
27113-22-0 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.592 ml | 17.96 ml | 35.921 ml |
| 5 mM | 0.718 ml | 3.592 ml | 7.184 ml |
| 10 mM | 0.359 ml | 1.796 ml | 3.592 ml |
| 5 mM | 0.072 ml | 0.359 ml | 0.718 ml |
Last Update：2024-01-02 23:10:35
27113-22-0 - Reference Information
| FEMA | 4665 | 1-(4-HYDROXY-3-METHOXYPHENYL)DECAN-3-ONE |
| Use | 5-deoxy-6-gingerol is an intermediate in organic synthesis and a pharmaceutical intermediate, mainly used in laboratory research and development process and chemical and pharmaceutical synthesis process. |
| biological activity | paradigm is a pungent phenolics found in Zingiberaceae. In mouse skin carcinogenesis, paraol binds to the active site of cyclooxygenase (COX-2), effectively inhibiting tumor development. |
Last Update：2024-04-09 20:49:11
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