14464-67-6

14464-67-6 - Names and Identifiers

Name	D-3-Trifluoromethylphe
Synonyms	H-D-PHE(M-CF3)-OH H-D-PHE(3-CF 3)-OH RARECHEM BK PT 0136 D-3-Trifluoromethylphe D-3-TRIFLUOROMETHYLPHE H-D-PHE(3-TRIFLUOROMETHYL)-OH D-3-Trifluoromethylphenylalanine D-3-TRIFLUOROMETHYLPHENYLALANINE 3-Trifluoromethyl-D-phenylalanine 3-TRIFLUOROMETHYL-D-PHENYLALANINE 3-(trifluoromethyl)-L-phenylalanine (2R)-2-ammonio-3-[3-(trifluoromethyl)phenyl]propanoate (R)-2-AMINO-3-(3-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID
CAS	14464-67-6
InChI	InChI=1/C10H10F3NO2/c11-10(12,13)7-3-1-2-6(4-7)5-8(14)9(15)16/h1-4,8H,5,14H2,(H,15,16)/t8-/m1/s1

14464-67-6 - Physico-chemical Properties

Molecular Formula	C10H10F3NO2
Molar Mass	233.19
Density	1.364±0.06 g/cm3(Predicted)
Boling Point	301.2±42.0 °C(Predicted)
Flash Point	135.9°C
Vapor Presure	0.000475mmHg at 25°C
Appearance	White powder
pKa	2.16±0.10(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.502
MDL	MFCD01860875

14464-67-6 - Risk and Safety

Hazard Symbols	Xi - Irritant
Safety Description	S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes.

14464-67-6 - Introduction

D-3-Trifluoromethylphe is an organic compound with the formula C9H9F3NO2. The following is a description of its nature, use, formulation and safety information:

Nature:
1. Appearance: Colorless crystalline solid.
2. Melting point: About 180-185 ° C.
3. Solubility: almost insoluble in water, soluble in ethanol, chloroform and other organic solvents.
4. Optical Activity: It is a D-isomer and has optical activity.

Use:
1. Pharmaceutical field: in pharmaceutical research, D-3-Trifluoromethylphe is often used as an intermediate for the synthesis of drugs.
2.3-(trifluoromethyl)-D-phenylpropionyl chloride can be prepared by reaction with acetyl chloride, which can be further used in organic synthesis.

Method:
The preparation of D-3-Trifluoromethylphe can be achieved through the following steps:
1. Diazotization of benzoic acid to obtain benzodiazoformic acid.
2. Benzenediazoformic acid and hydrochloric acid are reacted to obtain benzodiazoformate.
3. Benzenediazoformate is reduced to give 3-amino-D-phenyl acrylic acid.
4.3-amino-D-phenyl acrylic acid is reacted with trifluoromethyl O-phenyl dithione to give D-3-Trifluoromethylphe.

Safety Information:
With regard to D-3-Trifluoromethylphe safety information, it is necessary to strictly follow relevant safety procedures and personal protective measures when operating in laboratories and pharmaceutical facilities. The specific toxicity and danger of this compound has not been reported and therefore requires adequate evaluation and careful handling. At the same time, avoid contact with skin, eyes and respiratory tract. If contact is not careful, rinse with plenty of water immediately and seek medical attention. Always store it in a closed container resistant to organic solvents, away from ignition and organic matter.

Last Update：2024-04-09 21:54:55

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