2-(2-AMINOPHENYL)INDOLE
2-(2-aminophenyl)indole
CAS: 32566-01-1
Molecular Formula: C14H12N2
2-(2-AMINOPHENYL)INDOLE - Names and Identifiers
| Name | 2-(2-aminophenyl)indole |
| Synonyms | 2-(2-AMINOPHENYL)INDOLE 2-(2-aminophenyl)indole 2-(2'-AMINOPHENYL)INDOLE 2-(1H-indol-2-yl)aniline 2-(1H-indol-2-yl)-Benzenamine Benzenamine, 2-(1H-indol-2-yl)- |
| CAS | 32566-01-1 |
| InChI | InChI=1/C14H12N2/c15-12-7-3-2-6-11(12)14-9-10-5-1-4-8-13(10)16-14/h1-9,16H,15H2 |
2-(2-AMINOPHENYL)INDOLE - Physico-chemical Properties
| Molecular Formula | C14H12N2 |
| Molar Mass | 208.26 |
| Density | 1.229±0.06 g/cm3(Predicted) |
| Melting Point | 154-155°C(lit.) |
| Boling Point | 437.9±20.0 °C(Predicted) |
| Flash Point | 248.8°C |
| Vapor Presure | 7.2E-08mmHg at 25°C |
| pKa | 16.53±0.30(Predicted) |
| Refractive Index | 1.726 |
2-(2-AMINOPHENYL)INDOLE - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
2-(2-AMINOPHENYL)INDOLE - Introduction
2-(lH-indol-2-yl) aniline is an organic compound with the chemical formula C14H12N2. It has an indole ring and a benzene ring in the molecule, and an amino group is attached to the indole ring.
2-(1H-indol-2-yl) aniline can be used as an organic synthesis intermediate for the synthesis of a variety of biologically active compounds. It can be used in drug research, especially in the development of anticancer drugs.
There are many methods for preparing 2-(1H-indol-2-yl) aniline, and one of the commonly used methods is through the condensation reaction of acetic anhydride. The specific steps are as follows:
1. Mix indole and aniline in an appropriate molar ratio.
2. Add catalyst and solvent, such as boron trifluoride and acetonitrile.
3. Stir the reaction mixture at the appropriate temperature and time.
4. The product was filtered, washed and dried.
Regarding the safety information of 2-(1H-indol-2-yl) aniline, the following points should be noted:
1. The compound may be irritating to the eyes, skin and respiratory tract, and appropriate protective equipment should be worn when in contact.
2. Avoid inhalation of dust or solution, avoid contact with the mouth and food.
3. Pay attention to the use of ventilation equipment during operation to ensure that the operating environment is well ventilated.
4. Storage should be placed in a dry, cool, dark place, away from the fire and oxidant.
5. If you come into contact with this compound, immediately flush the affected area with plenty of water and seek medical help.
Please note that this is only general information. The specific use and preparation of this compound should refer to relevant literature and operating instructions, and follow the laboratory's safety regulations.
2-(1H-indol-2-yl) aniline can be used as an organic synthesis intermediate for the synthesis of a variety of biologically active compounds. It can be used in drug research, especially in the development of anticancer drugs.
There are many methods for preparing 2-(1H-indol-2-yl) aniline, and one of the commonly used methods is through the condensation reaction of acetic anhydride. The specific steps are as follows:
1. Mix indole and aniline in an appropriate molar ratio.
2. Add catalyst and solvent, such as boron trifluoride and acetonitrile.
3. Stir the reaction mixture at the appropriate temperature and time.
4. The product was filtered, washed and dried.
Regarding the safety information of 2-(1H-indol-2-yl) aniline, the following points should be noted:
1. The compound may be irritating to the eyes, skin and respiratory tract, and appropriate protective equipment should be worn when in contact.
2. Avoid inhalation of dust or solution, avoid contact with the mouth and food.
3. Pay attention to the use of ventilation equipment during operation to ensure that the operating environment is well ventilated.
4. Storage should be placed in a dry, cool, dark place, away from the fire and oxidant.
5. If you come into contact with this compound, immediately flush the affected area with plenty of water and seek medical help.
Please note that this is only general information. The specific use and preparation of this compound should refer to relevant literature and operating instructions, and follow the laboratory's safety regulations.
Last Update：2024-04-09 21:21:28
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