Molecular Formula | C29H27F5N2O5S |
Molar Mass | 610.59 |
Density | 1.431±0.06 g/cm3(Predicted) |
Boling Point | 717.2±70.0 °C(Predicted) |
Solubility | 10 mM in DMSO |
pKa | 4.29±0.10(Predicted) |
Storage Condition | -20℃ |
In vitro study | SH-4-54 exhibits unprecedented cytotoxicity in human glioblastoma brain tumor hepatocytes (BTSCs), but not in human embryonic astrocytes. In addition, SH-4-54 effectively inhibits STAT3 phosphorylation and its downstream transcriptional targets. |
In vivo study | In BT73 orthotopic xenograft mice, SH-4-54 (10 mg/kg, I. P.) exhibited BBB permeability, effectively inhibited glial tumor growth, and inhibited pstat3. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 1.638 ml | 8.189 ml | 16.378 ml |
5 mM | 0.328 ml | 1.638 ml | 3.276 ml |
10 mM | 0.164 ml | 0.819 ml | 1.638 ml |
5 mM | 0.033 ml | 0.164 ml | 0.328 ml |