1452-94-4
Ethyl 2-chloronicotinate
CAS: 1452-94-4
Molecular Formula: C8H8ClNO2
1452-94-4 - Names and Identifiers
| Name | Ethyl 2-chloronicotinate |
| Synonyms | Ethyl 2-chloronicoti ETHYL 2-CHLORONICOTINATE Ethyl 2-chloronicotinate 2-CHLORONICOTINIC ACID ETHYL ESTER Ethyl 2-Chloro-3-pyridinecarboxylate ethyl 2-chloropyridine-3-carboxylate 2-Chloropyridine-3-carboxylic acid ethyl ester 2-Chloro-3-pyridinecarboxylic acid ethyl ester 2-Chloronicotinic Acid Ethyl EsterEthyl 2-Chloro-3-pyridinecarboxylate2-Chloro-3-pyridinecarboxylic Acid Ethyl Ester |
| CAS | 1452-94-4 |
| InChI | InChI=1/C8H8ClNO2/c1-2-12-8(11)6-4-3-5-10-7(6)9/h3-5H,2H2,1H3 |
| InChIKey | PMIMPBYTPPRBGD-UHFFFAOYSA-N |
1452-94-4 - Physico-chemical Properties
| Molecular Formula | C8H8ClNO2 |
| Molar Mass | 185.61 |
| Density | 1.2445 g/cm3(Temp: 25 °C) |
| Melting Point | 68 C |
| Boling Point | 78°C (0.1 mmHg) |
| Flash Point | 108.1°C |
| Vapor Presure | 0.0166mmHg at 25°C |
| Appearance | Transparent crystallization |
| Color | Colorless to Light yellow to Light orange |
| pKa | -1.32±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.5210-1.5250 |
| MDL | MFCD00674129 |
1452-94-4 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S60 - This material and its container must be disposed of as hazardous waste. S37 - Wear suitable gloves. |
| HS Code | 29333990 |
| Hazard Class | IRRITANT |
1452-94-4 - Introduction
Ethyl 2-choronicotinate (2-choronicotinic acid ester) is an organic compound with the chemical formula C8H7ClNO2 and a molecular weight of 181.60g/mol. It is a colorless to light yellow liquid with a special aroma.
Ethyl 2-chloronicotinate has a wide range of applications in pharmaceutical synthesis, organic synthesis, pesticide manufacturing and other fields. It can be used as an intermediate for pesticides, for the synthesis of insecticides and herbicides. In addition, it can also be used to synthesize other organic compounds, such as pharmaceutical intermediates, dyes and fragrances.
Ethyl 2-chloronicotinate can be prepared by the reaction of nicotinic acid with chloroacetic anhydride. Nicotinic acid was first dissolved in alcohol, then a catalyst was added, chloroacetic anhydride was added dropwise to the reaction system, and the reaction was carried out for several hours. Finally, the Ethyl 2-chloronicotinate product was obtained by purification by distillation.
Safety considerations are required when using or storing Ethyl 2-chloronicotinate. It is a flammable liquid, irritating to the skin and eyes, and may cause damage to the human body. Avoid direct contact when using, wear appropriate protective gloves and goggles, and ensure a well-ventilated workplace. During storage, it should be sealed and kept in a cool, dry place, away from fire and oxidizing agents.
Summary: Ethyl 2-chloronicotinate is an organic compound with a wide range of applications and can be used in pesticide manufacturing, drug synthesis and other fields. Its preparation is obtained by reacting nicotinic acid with chloroacetic anhydride. Pay attention to safety issues during use and storage to prevent damage to humans and the environment.
Ethyl 2-chloronicotinate has a wide range of applications in pharmaceutical synthesis, organic synthesis, pesticide manufacturing and other fields. It can be used as an intermediate for pesticides, for the synthesis of insecticides and herbicides. In addition, it can also be used to synthesize other organic compounds, such as pharmaceutical intermediates, dyes and fragrances.
Ethyl 2-chloronicotinate can be prepared by the reaction of nicotinic acid with chloroacetic anhydride. Nicotinic acid was first dissolved in alcohol, then a catalyst was added, chloroacetic anhydride was added dropwise to the reaction system, and the reaction was carried out for several hours. Finally, the Ethyl 2-chloronicotinate product was obtained by purification by distillation.
Safety considerations are required when using or storing Ethyl 2-chloronicotinate. It is a flammable liquid, irritating to the skin and eyes, and may cause damage to the human body. Avoid direct contact when using, wear appropriate protective gloves and goggles, and ensure a well-ventilated workplace. During storage, it should be sealed and kept in a cool, dry place, away from fire and oxidizing agents.
Summary: Ethyl 2-chloronicotinate is an organic compound with a wide range of applications and can be used in pesticide manufacturing, drug synthesis and other fields. Its preparation is obtained by reacting nicotinic acid with chloroacetic anhydride. Pay attention to safety issues during use and storage to prevent damage to humans and the environment.
Last Update：2024-04-09 21:00:56
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