201532-42-5
(R)-N-FMOC-2-Thienylalanine
CAS: 201532-42-5
Molecular Formula: C22H19NO4S
201532-42-5 - Names and Identifiers
| Name | (R)-N-FMOC-2-Thienylalanine |
| Synonyms | FMOC-D-THA FMOC-D-THI-OH Fmoc-D-2-Thi-OH FMOC-D-THIENYLALANINE FMOC-D-2-THIENYLALANINE FMOC-D-ALA(2-THIENYL)-OH (R)-N-FMOC-2-Thienylalanine Fmoc-D-3-(2-Thienyl)-alanine FMOC-3-(2-THIENYL)-D-ALANINE |
| CAS | 201532-42-5 |
| InChI | InChI=1/C22H19NO4S/c24-21(25)20(12-14-6-5-11-28-14)23-22(26)27-13-19-17-9-3-1-7-15(17)16-8-2-4-10-18(16)19/h1-11,19-20H,12-13H2,(H,23,26)(H,24,25)/p-1/t20-/m1/s1 |
201532-42-5 - Physico-chemical Properties
| Molecular Formula | C22H19NO4S |
| Molar Mass | 393.46 |
| Density | 1.343±0.06 g/cm3 (20 ºC 760 Torr) |
| Melting Point | 169 °C |
| Boling Point | 623.4±55.0 °C(Predicted) |
| Flash Point | 330.8°C |
| Vapor Presure | 2.11E-16mmHg at 25°C |
| pKa | 3.59±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| Refractive Index | 1.5060 (estimate) |
| Physical and Chemical Properties | Overview (R)-N-FMOC-D-2-thienyl alanine, also known as N-fluorenoxycarbonyl-β-(2-thienyl)-D-alanine, is an unnatural amino acid. |
201532-42-5 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29309090 |
| Hazard Class | IRRITANT |
201532-42-5 - Nature
| melting point | 169 °C |
| boiling point | 623.4±55.0 °C(Predicted) |
| density | 1.343±0.06 g/cm3 (20°C 760 Torr) |
| refractive index | 1.5060 (estimate) |
| storage conditions | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| acidity coefficient (pKa) | 3.59±0.10(Predicted) |
Last Update：2024-04-10 22:29:15
201532-42-5 - Preparation method
In the current prior art, the preparation method of the non-natural amino acid N-fluorene methoxycarbonyl-β-(2-thienyl)-D-alanine and its intermediates is as follows: 2-thiophene methanol is acylated into 2-chloromethylthiophene by hydroxy chloride, and then mixed with sodium metal and ethanol and diethyl acetaminomalonate to synthesize diethyl ester, and then added D-acylase, the fmoc-d-thi-oh is prepared by reacting with fmoc-group. The operation process of this method seems simple, but it requires relatively expensive D-acylase, and the cost is high, so it is not suitable for commercial production.
Last Update：2024-04-10 22:29:15
201532-42-5 - Security information
| dangerous goods mark | Xi |
| safety instructions | 24/25 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| customs code | 29309090 |
Last Update：2024-04-10 22:29:15
201532-42-5 - Reference Information
| Overview | (R)-N-FMOC-D-2-thienyl alanine, also known as N-fluorenylmethoxycarbonyl-β-(2-thienyl)-D-alanine, is a non-natural amino acid. |
| preparation method | , the preparation methods of the unnatural amino acid N-fluorenylmethoxycarbonyl-β-(2-thienyl)-D-alanine and intermediates thereof are as follows: 2-thiophene methanol is acylated by hydroxy chloride to make 2-chloromethylthiophene, and then Diethyl ester is synthesized by mixing with metallic sodium, ethanol and diethyl acetomalonate, and then D-acylase is added to separate to obtain h-d-thi-oh, fmoc-d-thi-oh is obtained by reacting with fmoc-group. The operation process of this method seems simple, but it requires the use of relatively expensive D-acylase, and the cost is high, which is not suitable for commercial production. |
Last Update：2024-04-09 20:02:46
Supplier List
Featured ProductsSpot supply
Product Name: Fmoc-D-2-thienylalanine Visit Supplier Webpage Request for quotationCAS: 201532-42-5
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(thiophen-2-yl)propanoic acid Request for quotationCAS: 201532-42-5
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Product Name: Fmoc-D-3-(2-Thienyl)-alanine Request for quotation
CAS: 201532-42-5
Tel: +86 0512-69209928
Email: wuhao@highfine.com
merry@highfine.com
chenmengqi@highfine.com
QQ: 4006286883
CAS: 201532-42-5
Tel: +86 0512-69209928
Email: wuhao@highfine.com
merry@highfine.com
chenmengqi@highfine.com
QQ: 4006286883
Spot supply
Product Name: (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(thiophen-2-yl)propanoic acid Visit Supplier Webpage Request for quotationCAS: 201532-42-5
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Fmoc-D-Thi-OH Visit Supplier Webpage Request for quotationCAS: 201532-42-5
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: FMOC-D-2-THIENYLALANINE Visit Supplier Webpage Request for quotation
CAS: 201532-42-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 201532-42-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: Fmoc-D-2-thienylalanine Visit Supplier Webpage Request for quotationCAS: 201532-42-5
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(thiophen-2-yl)propanoic acid Request for quotationCAS: 201532-42-5
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Product Name: Fmoc-D-3-(2-Thienyl)-alanine Request for quotation
CAS: 201532-42-5
Tel: +86 0512-69209928
Email: wuhao@highfine.com
merry@highfine.com
chenmengqi@highfine.com
QQ: 4006286883
CAS: 201532-42-5
Tel: +86 0512-69209928
Email: wuhao@highfine.com
merry@highfine.com
chenmengqi@highfine.com
QQ: 4006286883
Spot supply
Product Name: (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(thiophen-2-yl)propanoic acid Visit Supplier Webpage Request for quotationCAS: 201532-42-5
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Fmoc-D-Thi-OH Visit Supplier Webpage Request for quotationCAS: 201532-42-5
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: FMOC-D-2-THIENYLALANINE Visit Supplier Webpage Request for quotation
CAS: 201532-42-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 201532-42-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History