1214265-58-3
WZ4003
CAS: 1214265-58-3
Molecular Formula: C25H29ClN6O3
1214265-58-3 - Names and Identifiers
1214265-58-3 - Physico-chemical Properties
| Molecular Formula | C25H29ClN6O3 |
| Molar Mass | 496.99 |
| Density | 1.303±0.06 g/cm3(Predicted) |
| Appearance | powder |
| Color | white to beige |
| pKa | 14.27±0.70(Predicted) |
| Storage Condition | -20°C |
| In vitro study | WZ4003 (3-10 μm) significantly inhibited nuak1-mediated phosphorylation of MYPT1 in HEK-293 cells expressing wild-type nuak1. In addition, WZ4003 (10 μm) inhibited MYPT1 Ser445 phosphorylation as well as cell migration, invasion, and proliferation to a similar extent to gene knockout in MEFs, or inhibition of NUAK1 in U2OS cells. WZ4003 also showed high specific affinity for the L858R/T790M mutant EGFR, while significantly reducing the IC50 of T790M in Ba/F3 containing cells. |
1214265-58-3 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.012 ml | 10.061 ml | 20.121 ml |
| 5 mM | 0.402 ml | 2.012 ml | 4.024 ml |
| 10 mM | 0.201 ml | 1.006 ml | 2.012 ml |
| 5 mM | 0.04 ml | 0.201 ml | 0.402 ml |
Last Update：2024-01-02 23:10:35
1214265-58-3 - Introduction
WZ4003 is a chemical compound whose specific properties include the following:
1. Structure: The chemical formula of WZ4003 is cThe molecular weight of WZ4003 is about 352.78g/mol.
2. Appearance: WZ4003 is white crystal or crystalline powder.
3. Melting point: The melting point of WZ4003 is about 138-142 degrees Celsius.
The primary use of WZ4003 is as an inhibitor of specific proteins or enzymes. Clinical and laboratory studies have shown that WZ4003 can inhibit the activity of MAP3K11 protein kinase, thereby affecting the regulation of related signaling pathways, such as JNK and p38 signaling pathways. This makes WZ4003 has potential application value in the research of cancer, inflammation and other diseases.
Regarding the preparation method, the preparation method of WZ4003 is relatively complicated, and organic synthesis methods are generally required to synthesize this compound. Specific synthetic routes can be found in related research papers.
When using WZ4003, you need to pay attention to its safety information. Because WZ4003 is a compound for laboratory research purposes, there is a lack of systematic toxicity and safety data, so it is necessary to follow relevant safety regulations and operating guidelines during the experimental operation. At the same time, when using WZ4003 should take appropriate personal protective measures, such as wearing gloves, goggles and protective clothing. In addition, WZ4003 should be kept away from fire and other flammable materials, and should be stored in a dry and well-ventilated place.
1. Structure: The chemical formula of WZ4003 is cThe molecular weight of WZ4003 is about 352.78g/mol.
2. Appearance: WZ4003 is white crystal or crystalline powder.
3. Melting point: The melting point of WZ4003 is about 138-142 degrees Celsius.
The primary use of WZ4003 is as an inhibitor of specific proteins or enzymes. Clinical and laboratory studies have shown that WZ4003 can inhibit the activity of MAP3K11 protein kinase, thereby affecting the regulation of related signaling pathways, such as JNK and p38 signaling pathways. This makes WZ4003 has potential application value in the research of cancer, inflammation and other diseases.
Regarding the preparation method, the preparation method of WZ4003 is relatively complicated, and organic synthesis methods are generally required to synthesize this compound. Specific synthetic routes can be found in related research papers.
When using WZ4003, you need to pay attention to its safety information. Because WZ4003 is a compound for laboratory research purposes, there is a lack of systematic toxicity and safety data, so it is necessary to follow relevant safety regulations and operating guidelines during the experimental operation. At the same time, when using WZ4003 should take appropriate personal protective measures, such as wearing gloves, goggles and protective clothing. In addition, WZ4003 should be kept away from fire and other flammable materials, and should be stored in a dry and well-ventilated place.
Last Update：2024-04-10 22:41:03
Supplier List
Spot supply
Product Name: N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)propionamide Request for quotationCAS: 1214265-58-3
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: WZ4003 Visit Supplier Webpage Request for quotationCAS: 1214265-58-3
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: WZ4003 Visit Supplier Webpage Request for quotationCAS: 1214265-58-3
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: WZ4003 Visit Supplier Webpage Request for quotationCAS: 1214265-58-3
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: WZ4003 Visit Supplier Webpage Request for quotation
CAS: 1214265-58-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1214265-58-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: N-(3-((5-chloro-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)propionamide Request for quotationCAS: 1214265-58-3
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: WZ4003 Visit Supplier Webpage Request for quotationCAS: 1214265-58-3
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: WZ4003 Visit Supplier Webpage Request for quotationCAS: 1214265-58-3
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: WZ4003 Visit Supplier Webpage Request for quotationCAS: 1214265-58-3
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: WZ4003 Visit Supplier Webpage Request for quotation
CAS: 1214265-58-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 1214265-58-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
1214265-58-3
固色交联剂P
50777-83-8
144177-62-8
对硝基苯硼酸
1,2-diphenylethanol
合成鞣剂MR102
新戊酰基乙腈
Benzoic aBenzoic acidcid
4-Dimethylamino-2-Methoxybenzaldehyde
固色交联剂P
50777-83-8
144177-62-8
对硝基苯硼酸
1,2-diphenylethanol
合成鞣剂MR102
新戊酰基乙腈
Benzoic aBenzoic acidcid
4-Dimethylamino-2-Methoxybenzaldehyde