Molecular Formula | C25H29ClN6O3 |
Molar Mass | 496.99 |
Density | 1.303±0.06 g/cm3(Predicted) |
Appearance | powder |
Color | white to beige |
pKa | 14.27±0.70(Predicted) |
Storage Condition | -20°C |
In vitro study | WZ4003 (3-10 μm) significantly inhibited nuak1-mediated phosphorylation of MYPT1 in HEK-293 cells expressing wild-type nuak1. In addition, WZ4003 (10 μm) inhibited MYPT1 Ser445 phosphorylation as well as cell migration, invasion, and proliferation to a similar extent to gene knockout in MEFs, or inhibition of NUAK1 in U2OS cells. WZ4003 also showed high specific affinity for the L858R/T790M mutant EGFR, while significantly reducing the IC50 of T790M in Ba/F3 containing cells. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.012 ml | 10.061 ml | 20.121 ml |
5 mM | 0.402 ml | 2.012 ml | 4.024 ml |
10 mM | 0.201 ml | 1.006 ml | 2.012 ml |
5 mM | 0.04 ml | 0.201 ml | 0.402 ml |