1135-23-5
3-(4-HYDROXY-3-METHOXYPHENYL)PROPIONIC ACID
CAS: 1135-23-5
Molecular Formula: C10H12O4
1135-23-5 - Names and Identifiers
1135-23-5 - Physico-chemical Properties
| Molecular Formula | C10H12O4 |
| Molar Mass | 196.2 |
| Density | 1.259±0.06 g/cm3(Predicted) |
| Melting Point | 87-93 °C |
| Boling Point | 120-130 °C(Press: 0.5 Torr) |
| pKa | 4.73±0.10(Predicted) |
| Storage Condition | Room Temprature |
| Physical and Chemical Properties | Bioactive Dihydroferulic acid (Hydroferulic acid) is one of the main metabolites of curcumin, which has antioxidant/free radical scavenging activity with IC50 value of 19.5 μM. Dihydroferulic acid is a metabolite of human intestinal flora and a precursor of vanillic acid. |
1135-23-5 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 2 |
| HS Code | 29189900 |
| Hazard Class | IRRITANT |
1135-23-5 - Upstream Downstream Industry
| Downstream Products | Tetrahydrocurcumin |
1135-23-5 - Nature
| Solubility | Soluble in dimethyl sulfoxide and methanol. |
| BRN | 2110370 |
Last Update：2024-04-09 18:58:34
1135-23-5 - Use 1 and Synthesis Methods
in vitro studies
Uptake of hydroxycinnamic acids by control, organic anion transporter 1 (OAT1), OAT2, OAT3, and OAT4 over expressing 293H cells. In 293H control cells, there was significant uptake of Dihydroferulic acid. The uptake of Dihydroferulic acid is also enhanced ~2-fold in the OAT1-expressing cells.
In vivo studies
Assessing the influence of an 11 weeks intervention with a resistant starch-enriched whole grain diet (HI-RS-WG, 25% RS) compared to a WG control diet (LOW-RS-WG, 6.9% RS) on serum profile of polyphenols (PPs) in 20 Zucker Diabetic Fatty rats. Five PPs were identified and quantified in serum samples of rats belonging to both intervention groups. HI-RS-WG rats had 2.6 folds higher serum concentrations of total PPs than LOW-RS-WG rats. An explorative data reduction approach, based on the Principal Component Analysis identified two principal components related to the gut microbiota fermentation and food intake, respectively. Results showed that the abundance of hippuric acid and Dihydroferulic acid in HI-RS-WG rats was explained by the stronger gut microbiota fermentation in those rats than in LOW-RS-WG rats.
Last Update：2024-04-09 21:11:58
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Product Name: 3-(4-Hydroxy-3-methoxyphenyl)propanoic acid Visit Supplier Webpage Request for quotationCAS: 1135-23-5
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