Molecular Formula | C13H12O3 |
Molar Mass | 216.23 |
Density | 1.285±0.06 g/cm3 (20 ºC 760 Torr) |
Melting Point | 165-166℃ (methanol ) |
Boling Point | 357.9±22.0 °C(Predicted) |
Flash Point | 217.8°C |
Solubility | Soluble in methanol, ethanol, ethyl acetate, insoluble in water |
Vapor Presure | 2.05E-07mmHg at 25°C |
Appearance | Pale yellow crystal |
pKa | 5.13±0.50(Predicted) |
Storage Condition | 2-8℃ |
Refractive Index | 1.668 |
Physical and Chemical Properties | Light yellow crystal, soluble in methanol, ethanol, ethyl acetate, insoluble in water, derived from the roots of the Polygonaceae plant sheep's hoof or Nepalese sheep's hoof. |
In vitro study | Nepodin (Musizin) exhibits significant IC 50 values that are 0.74 and 0.79 μg/ml against P. falciparum chloroquine-sensitive (3D7) and P. falciparum chloroquine-resistant (S20), respectively. |
In vivo study | Nepodin (Musizin) (orally administration; 2-10 mg/kg; 4 weeks) improves the impaired glucose tolerance of db/db mice, also decreases an increase in plasma insulin concentration of db/db mice in a dose-dependent manner. Animal Model: C57BL/KsJ-db/db mice Dosage: 2 mg/kg; 10 mg/kg Administration: Orally administration; 2-10 mg/kg; 4 weeks Result: Had antihyperglycemic potential and improved insulin resistance. |
biological activity | Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor, isolated from Rumex crispus. Nepodin (Musizin) stimulates the transport of GLUT4 to the plasma membrane by activating AMPK. Nepodin (Musizin) has anti-diabetic and anti-malarial effects. |
in vitro study | Nepodin (Musizin) exhibits significant IC 50 values that are 0.74 and 0.79 μg/ml against P. falciparum chloroquine-sensitive (3D7) and P. falciparum chloroquine-resistant (S20), respectively. |
in vivo study | Nepodin (Musizin) (orally administration; 2-10 mg/kg; 4 weeks) improves the impaired glucose tolerance of db/db mice, also decreases an increase in plasma insulin concentration of db/db mice in a dose-dependent manner. Animal Model: C57BL/KsJ-db/db mice Dosage: 2 mg/kg; 10 mg/kg Administration: Orally administration; 2-10 mg/kg; 4 weeks Result: Had antihyperglycemic potential and improved insulin resistance. |
Animal Model: | C57BL/KsJ-db/db mice |
Dosage: | 2 mg/kg; 10 mg/kg |
Administration: | Orally administration; 2-10 mg/kg; 4 weeks |
Result: | Had antihyperglycemic potential and improved insulin resistance. |
Chemical properties | Light yellow crystals, soluble in methanol, ethanol, ethyl acetate, insoluble in water, derived from the roots of the Polygonaceae plant sheep's hoof or Nepalese sheep's hoof. |