DU125530 MedChemExpress (MCE)

Product Name	1,2-Benzisothiazol-3(2H)-one,2-[4-[4-(7-chloro-2,3-dihydro-1,4-benzodioxin-5-yl)-1-piperazinyl]butyl]-,1,1-dioxide
Synonyms	DU125530;1,2-Benzisothiazol-3(2H)-one,2-[4-[4-(7-chloro-2,3-dihydro-1,4-benzodioxin-5-yl)-1-piperazinyl]butyl]-,1,1-dioxide
CAS	161611-99-0
EINECS
Chemical Formula	C23H26ClN3O5S
Molecular Weight	491.99
inchi
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Descriptions	DU125530 DU125530 MedChemExpress (MCE) HY-19283 161611-99-0 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions DU125530 DU125530 MedChemExpress (MCE) HY-19283 161611-99-0 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. DU125530 is a potent and selective5-HT1A receptor antagonist with Ki values of 0.7, 890, 1200, 240, 750, 1100 nM for 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2C, 5-HT3, respectively. DU125530 shows antidepressant effects. DU125530 (3 mg/kg s.c.) reduces the reduction of 5-HT release induced by 8-OH-DPAT (HY-112061) in wild-type mice[1]. 5-HT1A Receptor 0.7 nM (Ki) 5-HT1B Receptor 890 nM (Ki) 5-HT1C Receptor 1200 nM (Ki) 5-HT2A Receptor 240 nM (Ki) 5-HT2C Receptor 750 nM (Ki) 5-HT3 Receptor 1100 nM (Ki) \| \| \| \| \| \| \| \| \| \| [1]. Mos J, et al. The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons. Eur J Pharmacol. 1997 May 1 325(2-3):145-53. [Content Brief] [2]. Scorza MC, et al. Preclinical and clinical characterization of the selective 5-HT(1A) receptor antagonist DU-125530 for antidepressant treatment. Br J Pharmacol. 2012 Nov 167(5):1021-34. [Content Brief]
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Last Update	2025-05-21 16:50:25

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